Correlationship Study Of Serum AGEs And Plasma AngⅡ On Essential Hypertensives With Left Ventricular Hypertrophy

Backgrounds and ObjectivesThe hypertension shows a gradual increase trend in the incidence with the development of sociometric and technological level,as well as change of social psychology, life style and food habits.Though a number of people pay extensive attention on it, the pathogenesis of EH is not clear yet.Majority think the pathogenesis involves interaction of environment and genetic factors.EH can affect hemodynamics major organs such as heart, brain, kidney, et al,and change its structure and function.There are about 23%-48% of the EH patients who complicate with left ventricular hypertrophy. The incidence rate of myocardial ischemia, heart failure, arrhythmia even Sudden Cardiac Death is higher than normal when LVH existence caused by EH.As one of pathogenic factors in the EH combined LVH, the important role of angiotensinⅡhas been confirmed.With Renin-Angiotensin-Aldosterone System (RAAS) was activating, AngⅡin circulation and tissue are increased while elevating blood pressure, promoting fibrosis and regulate the level of information material indirectly.Recently, data indicate that advanced glycosylation end products (AGEs) and the receptor for advanced glycosylation end products (RAGE) system was involved in the formation. The development of cardiovascular disease with the progress of the study about AGEs and RAGE.AGEs take part in the development of angiocardipathy with the reason of promoting fibrosis. Some of the studies have shown that the AGEs expression can be inhibited by ARB and ACEI of certain organs and tissues in animals, so speculated that there is cross-talk between RAAS and AGEs-RAGE system in the nosogenesis. However, the pathogenesis of AGEs in the EH complicated LVH is indistinct, the possible relationship between AGEs and AngⅡin the development of EH and EH complicated LVH has not been reported currently.This study discuss the possible relationship and correlation of serum AGEs and plasma Ang II of object by measuring their level in the patients with EH and EH combined LVH. Try to find the relationship between AGEs and AngⅡand their role of the pathogenesis of EH and EH complicated LVH,in order to provide a theoretical basis for prevention and treatment research.MethodsThe blood pressure, heart rate, height, weight, left ventricular mass (LVM),left ventricular mass index (LVMI),and body surface area (BSA) of subjects were recorded.According to the diagnostic criteria of blood pressure (SBP≥140mmHg and (or) DBP≥90mmHg) from 2005 revised edition China hypertension guidelines, and the diagnostic criteria (LVMI values, male>125g/m2,female>110g/m2) from 2007 ESH/ESC hypertension guidelines, seek out the EH group(85 cases),including the EH not complicated LVH(EHNLVH group)(52 cases) and EH complicated LVH (EHLVH group)(33 cases).Then set control group from normal people (50 cases). The content of Serum AGEs and plasma AngⅡwere measured respectively by double antibody sandwich enzyme immunoassay (ELISA) method and radioimmunoassay (RIA) method.Then compare the differences of indicators between the two groups to analyze their correlation.Exclude the diseases from object secondary hypertension, diabetes, renal damage, severe liver kidney disease, apoplexy, hyperthyroidism, severe anemia, malignant tumor, peripheral vascular diseases,cor pulmonale, hypertrophic cardiomyopathy, congenital heart disease, valvular heart diseases, and pregnancy, etc.Applicating SPSS13.0 for the measured data results were analyzed statistically, The significant difference is P<0.05 for the data.Results1.Comparing with normal group, level of the serum AGEs and plasma AngⅡin EHNLVH group and EHLVH group are both higher (P<0.05),while EHLVH group increased more significantly (P<0.01).2.It was showed by Correlation analysis that the content of AGEs and AngⅡin patients with EH was positively correlated (r=0.627 P<0.01);LVMI value and the content of AGEs (r=0.471 P<0.01)were positively correlated;as well as the AngⅡ(r =0.516 P<0.01).3.Regression analysis shows that AGEs and AngⅡare both the risk factors for the pathogenesis of LVH.ConclusionAGEs and AngⅡare both take part in the mechanism of the occurrence and development of EH and LVH. It do have interaction relationships between RAAS and AGEs-RAGE system in pathogenesis of EH and EH complicated LVH.