Ziqian Mixture Clinical Observation Of Patients Withcitpand The Impact On The Fas

Objective:To observe the effects of death factor Fas level in peripheral blood of zi qian mixture to patients with Chronic Idiopathic thrombocytopenic purpura(CITP) to explore the pathogenesis of Chronic Idiopathic thrombocytopenic purpura(CITP),for the drug to provide the theoretical basis for further clinical appliation.Methods:30 CITP patients were given to zi qian mixture as a course of treatment for two months,then determine the efficacy after two courses of treatment and changes of Fas level before and after treatment in patients with CITP was measured by Flow Cytometry.Results:1.Total effective rate of treatment of zi qian mixture with CITP was 86.67%,On the treatment before,after treatment the total symptom score and the clinical result of platelet count to do paited t test, and shows statistical significance(P<0.01).2.The expression levels of death factor Fas in CITP patients group were significantly lower than the normal controlled group in peripheral blood,it increased after treatment,the matching t test of the differences of the results before and after treatment also shows statistically significant (P <0.01).Conclusions:1. zi qian mixture for the treatment of CITP is effective,the total effective rate was 86.67%.2.The experiments show that the level of death factor Fas of CITP patients was lower than nomal people,3.low expression of Fas of CITP patients may affected the normal apoptosis of T lymphocytes, and maybe involvde in the occurrence of CITP.4.ziqian mixture may achieve the purpose of the treatment of CITP by regulateing Fas levels of patients with CITP and promote normal apoptosis of T lymphocytes.