| Objective:To observe the effect traditional Chinese medicine(TCM) of BuShenHuoXue on primary visual cortex damage in rat model of chronic, elevated intraocular pressure, and explore the mechanism of it initially.Methods:By unilaterally cauterizing 3 episcleral vessels,the rat model of chronic, moderately elevated intraocular pressure was gotten.30 rats were divided into 3 groups randomly:model group, treatment group,and normal control group.After given drugs or normal saline for 8 weeks,the rats were put to death. To observe the effection by intraocular pressure(IOP), content of nissl bodies,expression of brain-derived neurotrophic factor,ultrastructure of neuron cell in the primary visual cortex (PVC)Results:Chronic elevated intraocular pressre was gotten and there was an approximately 3-fold increase in IOP for 2 months comparing to pre-models building. The Intervention:BuShenHuoXue of TCM can lower IOP slightly, and increase content of nissl bodies,enhance expression of brain-derived neurotrophic factor, and improve ultrastructure of neuron cell.Conclusion: This model is simple and stable, and moderately elevated IOP can last at least 2 months. BuShenHuoXue of TCM can protect the visual function from elevating intraocular pressre,by increasing content of nissl bodies,enhancing expression of brain-derived neurotrophic factor,improving ultrastructure of neuron cell.
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