Experimental Study Of Ke Chuan Wan Treatment Of Chronic Bronchitis

Chronic bronchitis is a medical common disease, with the main clinical manifestations such as chronic cough, phlegm, wheezing. Patients often relapse due to chronic, prolonged unhealed, and the concurrent emphysema, pulmonary heart disease, significantly affect the labor force, even life-threatening. Therefore, how to prevent and treat the chronic bronchitis is an important issue of the medical profession. Generally believed that, when the body resistance subside, in the presence of airway sensitivity to different degrees, based on the existence of one or several external factors, including infection, physical and chemical factors, climate, smoking and other factors, can develop into a long-term effect of chronic repeated bronchitis, in addition to the increase in recent years, environmental pollution and the overuse of antibiotics, anti-infection and symptomatic Western medicine treatment markedly have a power of a single micro effect.The western medicine for the treatment of acute and chronic bronchitis made of mainly symptomatic and supportive treatment, infection control, expectorant cough and spasm and asthma, which control the disease, relieve symptoms is an effective way. But there are still no good solutions to many problems and because of the abuse of antibiotics to result in resistant bacteria, and difficulty of treatment increasing, a considerable proportion of patients develop into emphysema, pulmonary heart disease. Exploring a kind of new treatments becomes a top priority. The characteristics and advantages of Chinese medicine treatment of chronic bronchitis, therefore, it will be significant social and economic benefits to play a feature of Chinese medicine to strengthen the basic and clinical research chronic bronchitis and reduce the recurrence rate of chronic bronchitis, to relieve symptoms. The topic selected KCW with effects of drying damp and strengthening spleen, regulating qi-flowing for eliminating phlegm, ventilating the lung, arresting cough and relieving cough and asthma. Because prescription combination and compatibility of medicines is unique, there is a significant effect in clinical use the treatment for chronic bronchitis, bronchial asthma, emphysema caused by asthma, chest tightness, cough, sputum embolism for years. Test animals were randomly grouped, normal or model group to be the control, choosing a similar efficacy and indications Maxing with cough medicine tablets, as a positive control group, the relevant test set ambroxol tablets, paracetamol and dihydrocodeine can be Western medicine due to the positive control group piece to ensure the reliability of test methods. Drugs tested by clinical doses of 5 times,10 times,20 times,30 times with 3 dose groups, respectively (rats, guinea pigs and pigeons to set up 5 times,10 times,20 times, mice to set up 10 times, 20 times,30 times). To investigate the effect of KCW prevention and treatment of chronic bronchitis, chronic bronchitis experimental animal models were adopted by smoking. In order to investigate the role of KCW cough, cough method such as ammonia water in mice and guinea pigs citrate were selected. In order to investigate the role of phlegm, the use of phenol red method section of mouse trachea, tracheal cilia movement method pigeon, rat tracheal sputum volume and tracheal secretions of proteoglycan content were chosen.KCW can improve the inflammation changes in lung and bronchus tissue of the animal model of chronic bronchitis and tracheal epithelial basic integrity of the pseudostratified ciliated columnar epithelium, ciliated cells visible on the surface, occasional goblet cells, scattered lymphocytes occasionally the submucosa. No thin alveolar wall congestion, alveolar space clear, and no exudate, bronchial epithelial integrity, cell loss and inflammatory cell infiltration, suggesting that the preventive effects of chronic bronchitis. KCW with cough effects that can significantly reduce Ammonia cough frequency in mice and significantly prolonged cough latency; reduce the number of citric acid induced cough in guinea pigs, and significantly prolonged cough incubation period. KCW with phlegm pill effect can significantly increase the mouse trachea segment phenol red excretion; increase the pigeon tracheal cilia movement; increase the amount of rat tracheal sputum and tracheal secretions in the mucopolysaccharide content suggest a cough pill expectorant effect. In summary, KCW with the role of prevention and treatment of mice with chronic bronchitis, and has cough, phlegm. The finding for KCW with drying damp and strengthening spleen, freeing lung and relieving asthma, resolving phlegm to relieve cough and treatment chronic bronchitis, bronchial asthma, chest tightness, cough, sputum caused by emphysema provides a pharmacological basis.