The Study On Anti-inflammatory Compound Mongolian Medicine Of Its Screening And Effects

Objective: To study on the screening of anti-inflammation compound mongolian medicine and its anti-inflammatory effects and mechanism.Methods: Make the permeabitity of blood capillaries and cotton pellet-induced granuloma method by the xylene-induced inflammation, paw swelling, acetic acid to in mice. Determine the ear swelling, paw edema caused by egg white and formaldehyde and cotton pellet induced granuloma after administration.The adjuvant arthritis (AA) rat model was made. Then, the activity of IL-1β,IL-6 and TNF-αof AA rat was determined with the method of ELISA.Results: HuaJiao -6 decoction significantly inhibited the acute inflammation in mice induced by xylene as well as the acetic acid to make the permeabitity of blood capillaries and subacute inflammation model caused by egg white and formaldehyde and the chronic inflammation model aroused by intradermal implantation cotton pellet . The Content of IL-1β,IL-6 and TNF-αin serum of AA rat significantly reduced by HuaJiao -6 decoction.Conclusion: HuaJiao -6 significantly inhibitive on inflammation. HuaJiao-6 decoction had the inhibitory effect on the activity of inflammatory mediums and responds well to treating RA.