The Study Of Related Risk Factor In Patients Of Cerebral Infaction With Leukaraiosis

Background and Objective:Leukoaraiosis (LA) was put forward first by Hachinski in 1987 as an imaging noun.It is a common image changes in elderly people. LA is closely linked with the prognosis of ischemic stroke, cerebral micro-hemorrhage, cognitive impairment, myocardial infarction, late-onset depression, but the specific pathogenesis remains unclear. Human plasma lipoprotein associated phospholipase A2 (Lp-PLA2) is a new inflammatory markers, and a large number of studies have shown that it is a very meaningful indicator of prediction of cerebrovascular events.But the study between Lp-PLA2 and LA is less.The text mainly analyze the relationship between Lp-PLA2 and LA and other related risk factors in patients of cerebral infarction with leukoaraiosis and to investigate their pathogenesis.Methods:In this study, we selected 178 cerebral infarction patients in neurology ward in the first hospital of Jilin university from May 2010 to March 2011. All patients are divided into a cerebral infarction with leukoaraiosis (LA group) and a cerebral infarction without leukoaraiosis (no LA group). We compare their Lp-PLA2 levels and clinical, laboratory examinations. Clinical datas include age,gender,hypertension diabetes,hyperlipidemia,the history of smoking and alcohol consumption and coronary heart disease, lacunar infarction; Laboratory datas include low-density lipoprotein cholesterol,triglycerides,cholesterol,fasting glucose,systolic blood pressure on admission,diastolic blood pressure on admission and cerebral vascular situation. Cerebral vascular stenosis is divided into anterior circulation disease, posterior circulation disease, and both of them. Calculation datas use t test and count datas use x2 test.The indicators which have statistical significance in univariate analysis are imported into the logistic multivariate regression model.Results:(1)The incidence of LA was 46.63% in 178 patients with cerebral infarction. (2)Univariate analysis result:There are significant differents between LA group and no LA group in age,systolic blood pressure on admission,Lp-PLA2,history of hypertension and lacunar infarction.After the logistic multivariate regression We screen out three indicators with statistical significance:Lp-PLA2 (P=0.000, OR=1.234),age (P=0.023, OR=1.061),lacunar infarction. (P=0.096, OR=2.809).Lacunar infarction has the most relevance with LA. (3) There is no significant difference berween LA group and no LA group in gender,diabetes,hyperlipidemia,the history of smoking and alcohol consumption,coronary heart disease and cerebral vascular stenosis. (4)There is no significant difference between two groups in low-density lipoprotein cholesterol,triglycerides,cholesterol of hyperlipidemia and fasting glucose of diabetes (P>0.05). After cerebral vascular stenosis is divided into anterior circulation disease, posterior circulation disease, and both of them,the proportion is no significant difference between two groups (P>0.05).Conclusion:(1)Lp-PLA2, lacunar infarction is an independent risk factor for LA.(2)There is a lack of a relationship between cerebral large artery stenosis and LA. (3) Hypertension is an important risk factor for LA, especially the elevated systolic blood pressure.(4) The risk factors in LA and the ischemic stroke are the same risk factors, including diabetes,hyperlipidemia,the history of smoking and alcohol consumption and coronary heart disease...