Clinical Study On Relation Between P-selectin And Deep Venous Thrombosis Forecast During Perioperative Hip Replacement

Objective:To investigate the value of clinical diagnosis and threshold for the diagnosis on P-selectin during perioperative hip replacement.Methods:Select the 102 patients with single hip replacement in the hospital from October 2007 to March 2010, Surgical approaches are used lateral hip incision; The patients with the preoperative and postoperative 2,4,7 days or the limb swelling does not go away need the deep venous color dppler examination, Normal control group are the 50 healthy people with the same period in our hospital.according to color doppler examination,the patients were divided into DVT group and non-DVT group, which compared with the healthy group. Collect the plasma of patients who are fasting before and after operation early in the morning; Determinate the content of the P-selectin in plasma by ELISA (Enzyme linked immunosorbent assay) and draw ROC curves (Receiver operating characteristic curve)in patients after hip replacement using the SPSS and the originPro8.0.Results:There was no statistical difference on the content of the P-selectin between the DVT group and the non-DVT group and the Normal control group before surgery, but there was statistics different after surgery. the AUC (Area under the curve)is 0.716 using the SPSS 11.0. Draw the ROC curve using the originPro8.0 with the sensitivity for the vertical and 1-specificity for the horizontal in a different point.Determine the 42 ng·mL-1 as the best diagnostic threshold, through selecting the top-left point in the curve and combinning the sensitivity.Conclusion:P-selectin play an important early warning role and diagnosis in DVT during perioperative hip replacement.It was the>42 ng·mL-1 for the diagnosis of the DVT as the best threshold.