Clinical Research On Renal Failure No. Ⅱ Recipe Delaying CRF

CRF has attributed to various causes of chronic progressive renal damage, kidneys can not maintain its normal function, thereby, azotemia, metabolic disorders and the involvement of various systems and a series of clinical symptoms of the syndrome. That is a common clinical disease difficult. Discussion of Chinese medicine in order to delay the development of chronic renal disease of great clinical significance.In this thesis, including clinical research, experience, inheritance and literature review of three parts.The first part, " Clinical observation on Renal Failure No. II recipe delaying CRF".Objective:To investigate Clinical observation on modified Renal Failure No. II recipe delaying CRFMethod:To select the First Hospital of Wuhan renal outpatient CRF I-III of 48 patients, divided according to TCM spleen and kidney deficiency type, spleen and kidney yang, Qi and Yin Deficiency type, liver-kidney, yin and yang deficiency for modified Renal Failure No. II recipe Treated for 2 months. Main clinical effect observed before and after treatment, and efficacy of Western relations in different stages, Chinese medicine type effects, and biochemical levels of serum creatinine (Scr), blood urea nitrogen (BUN), creatinine clearance rate of endogenous (Ccr), hemoglobin (Hb) of change.Results:1 Syndromes of CRF patients:48 patients, the spleen and kidney Qi deficiency Syndrome in 16 cases,33.3%; spleen deficiency syndrome in 14 cases,29.1%; liver kidney yin deficiency syndrome in 7 cases,14.6%; 6 cases of Qi and Yin deficiency, accounting for 12.5%; deficiency of both yin and yang in 5 cases,10.4%. And turbid damp syndromes in 16 cases, 33.3%; heat card 13 cases,27.1%; blood stasis syndrome in 11 cases,22.9%; heat toxicosis in 5 cases,10.4%; wind card in 3 cases, accounting for 6.3%.2 Biochemical improvement after treatment compared to the situation changes:48 patients were treated Scr, BUN, decreased compared with before treatment, Ccr, Hb increased compared with before treatment, and the difference was statistically significant (P<0.01, P<0.05).3 Clinical comparison:48 patients, treated 14 cases markedly effective in 17 cases, stable in 12 cases,5 cases ineffective, the total effective rate 64.6%,89.6%stable efficiency.4 Comparative efficacy of TCM type:48 cases, spleen and kidney and spleen and kidney yang deficiency type the total effect, accounting for 87.5%and 85.7%; spleen and kidney and spleen and kidney yang deficiency type more effective than liver-kidney, Qi and Yin Deficiency type and yin and yang deficiency, with statistical significance (p<0.05).5 Comparative efficacy of clinical stage:48 cases, compensation of the total effective rate was 72.7%, decompensated total effective rate was 68.8%, failure of the total effective rate was 40%. Compensation, and decompensation and failure of clinical efficacy, the difference was not statistically significant (P> 0.05).6 side effects:treatment,3 patients had diarrhea (more than 3 times a day), by reducing the amount of rhubarb, the symptom relief, we found no other adverse reactions. Conclusion:1 Renal Failure No.â…¡recipe has some clinical efficacy of delaying CRF,syndromes of spleen and kidney qi (yang) were more effective.2 Renal Failure No.â…¡recipe can reduce the serum creatinine and urea nitrogen levels, improve renal anemia, the protection of renal function, delaying the progress of CRF has a certain effect.3 Renal Failure No.â…¡recipe using CRF, fewer adverse reactions, safety,good, worthy of promotion.The second part, "Management of CRF Guan Professor of Clinical Syndrome experience. " Mainly from the Chinese name of disease of CRF, etiology and pathogenesis, TCM treatment characteristics, with integrated Chinese and Western treatment methods, etc. Prof. summary finishing Jing Huan Guan clinical experience of the treatment of CRF. Tube old view that the ill-bit, mainly in the kidney, renal system is based on the multi-centric disease, organs damage. Of CRF for black, short, true, stasis, turbid 5 performance, with reference to its poisonous cloud of virtual stasis between the folders, the virtual machine standard features of actual illness, possession of fourth eldest among the attending co-reference rule proposed by the treatment of CRF six, that is, spleen qi law, nourishing liver and kidney Law, Law of the blood and blood, promoting blood circulation method, detoxification and Turbidity, Ruanjian Sanjie law; Identified the disease in combination with trace elements such as Meridian and the principles of drug selection, optimize the set of square. Advocates an integrated combination of Chinese and Western medicine treatment of CRF, elevated creatinine for a variety of factors caused to proceed, each break is not directly against creatinine, but creatinine played down to protect renal function results.The third part is literature review.The first chapter "CRF in medical research overview", focuses on knowledge of TCM for CRF, Chinese medicine treatment of CRF status and the progress of the study the mechanism of TCM. From the etiology and pathogenesis of CRF awareness syndrome type on governance, specifically Hosen side treatment, addition and subtraction with the disease, Chinese medicine, and single herb in Chinese medicine research, to the combination therapy, experimental research in the field introduced in treatment of chronic the progress of renal failure. The Second, "CRF of TCM Quantitative Research" to discuss the standardization of TCM, the objective of syndrome diagnosis, quantification, standardization. Mainly from a clinical, based on the summary, experts, development of dialectical standards; symptoms graded measurement methods; the use of modern technology by means of literature study the establishment of macro-dialectical standards; Chinese medicine and Western medicine biochemical syndrome; trace element indicators and TCM syndrome type; Pathological Morphology and Differentiation of various types of relations; syndrome type detection and imaging indicators of relationship; Syndromes and tongue, pulse-oriented research in the field of objective description on CRF of TCM quantitative research.