| Objective:Reflux esophagitis(RE) is a chronic esophageal mucosal injury, is a common clinical esophageal motor dysfunction in inflammatory disease is a chronic recurrent disease. With the social development, the acceleration of the pace of life, it increases the psychological pressure, RE gradually increased the incidence rate; the development and popularization of the endoscopic detection rates were making its trend year by year. The RE patients, especially elderly people mostly due to human aging, organ cells decreased, organ atrophy, so that the elderly and young adults anatomical and physiological functions significantly different, clinical symptoms with various refractory, lesion weight, easy to diagnose and high recurrence rate, and prone to cause oropharyngeal and respiratory-related disease is characterized by, so the elderly should be enhanced to improve the level of RE research and treatment. But the side effects of traditional western medicine is not only large, high recurrence rate, and the heavier the financial burden of long-term treatment.At present, more and more clinical reports show that Chinese medicine in the treatment of RE has a greater benefit.In this study, elderly patients as the research object, according to its characteristics, based on the principle of Shugan and stomach treatment, using ShiGuanning-the self experience prescription of Professor Gan Aiping to conduct clinical treatment and research. Designed to observe the clinical efficacy and safety of SGN, from the theoretical and clinical trials to explore two aspects of the mechanism of SGN, objective evaluation of its effectiveness and safety, provide a theoretical basis for clinical application.Methods:Western diagnosis of reflux esophagitis, Chinese medicine of the disharmony of liver and evidence for the 60 elderly patients, according to the order of treatment were randomly divided into treatment group and control group. Treatment group,30 cases received the treatment of traditional Chinese medicine prescriptions SGN; control group of 30 cases was treated with Omeprazole plus. To 6 weeks as a course of treatment. Observed before and after treatment of clinical symptoms, endoscopic efficacy, symptom scores of traditional Chinese medicine, comprehensive efficacy, relapse rate, etc, and statistical analysis.Results:①Two groups after treatment with endoscopic lesions by statistical analysis, there were significant differences in the two groups. (P<0.01)②The efficacy of endoscopic comparison of two groups after treatment:treatment group, cure rate of 56.00%, significant efficiency is 20.00%, efficiency of 13.33%, inefficiency of 10.00%, the total efficiency was 90.00%. The control group, cure rate of 36.67%, significant efficiency is 13.33%, efficiency of 16.67%, inefficiency of 33.33%, the total efficiency was 66.67%. The total effective rate in the treatment group was significantly higher than the control group.③The symptom score after the treatment and after three months:two pairs of points on TCM syndromes were all significantly improved (P<0.01), but the symptom scores of the treatment group is more effective than the control group after the treatment and after three months (P<0.05). Implying that SGN has significantly improved the efficacy of TCM, much better than the western medicine group.④The treatment group improved, such as epigastric fullness or pain threat, acid regurgitation, hiccups, anorexia and other individual symptoms, compared with the control group, has no significant differences (P>0.05), but the two groups in the improvement of heartburn, belching, emotional depression, good heave a deep sigh, epigastric noise and so on were significant differences (P<0.05), the treatment group is better than the control group.⑤The comprehensive effect after treatment:The treatment group cure rate was 53.33%, significant efficiency was 23.33%, efficiency of 16.67%, inefficiency of 6.67%,the total efficiency was 93.33%. The control group, cure rate of 30.00%, significant efficiency was 20.00%, efficiency of 23.33%, inefficiency of 26.67%, the total efficiency was 73.33%. After statistical analysis, the two groups have significant difference in integrated effect after treatment, the treatment group was better than the control group (P<0.05).⑥Recurrence rate between two groups:the recurrence rate of treatment group was 13.33%,43.33% of the control group. The recurrence rate of control group was significantly higher than the treatment group (P<0.01). Prompt that SGN has much more advantage on the radical of eldly RE.Conclusion:The clinical trial results showed that, the Chinese prescription, SGN,has much more advantages than the western medicine, such as antacids, dynamic medicine. SGN not only significantly reduced elderly RE patients with clinical symptoms and endoscopic lesions, and low recurrence rate of gastroscopy.In the course of medication was not found toxic damage in heart, liver, kidney and other vital organs and hematopoietic system. SGN is a safe and effective clinical treatment, worthy of further research and extension.
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