| Objective:To investigate the effect and safety and inquire the mechanism of the traditional Chinese herb medicine SGN on reflux esophagitis, and through clinical experimental study, probe into the function mechanism of the SGN on the reflux esophagitis instead, offer the theoretical foundation for its clinical practice.Method:1. selected of The target(1) selected is above the age of 18;(2) Accord with the diagnostic standard(3) There are heartburn, instead sour, such symptoms as the pain, etc. after brestbone in various degree in clinical manifestation;(4) Through Chinese medicine is dialectical it is not a liver stomach with the main disease of card:2. Get rid of the target(1) Do not accord with the above-mentioned standards selected;(2) Gestation or the women breast-feeding their children;(3) Amalgamate cardiovascular disease, chronic lung disease, esophagus narrow with tumour, gastritis, ulcer, operation history, other stomach power obstacle disease, diabetes and connective tissue disease, disease of biliary tract and gallbladder of stomach of digesting etc. of withering etc..3. 100 patients of reflux esophagitis from the outpatient department were divided randomly into to groups :the treatment group and the control group. There were 50 patients in each group without significant in sex, age, symptom pattern between two group(p>0. 05).4. The control group taking Omeprazole 20mg, twice daily and Motilium 10mg, third daily.The treatment group taking traditional Chinese herb of SGN , one pill daily and taking Omeprazole and Motilium. The treatment time was composed of 6 weeks.5. Reexamined the gastroscope by the same doctor, is dealt with by statistics after a course of treatment, treat displaying and two groups of always efficient, fully recovering rate under gastroscope from beginning to end relatively.6. Write down relevant symptoms (heartburn, instead sour, the pain and liver stomach after brestbone are not with the symptom of the card), write down once every 2 weeks, do statistics to deal with, compare two groups of always efficient and fully recovering rate.7. Check blood in the urine routine and liver kidney function as the security index every 2 weeks, in order to confirm whether the peaceful soup of traditional Chinese medicine esophagus is a poisonous side effect.8. Will reexamine the gastroscope again in 6 weeks in treating the effective patient, will observe the situation of recuring, dealt with by statistics, compare two groups of long-term curative effect.Result:1. Compared with the situation before treating the esophagitis degree, pass Ridit analysis after two groups of patients treat, there is a significance difference (p<0. 01).2. Curative effect is compared, is dealt with by statistics under two groups of patient' s gastroscope, always have significance difference (p<0. 05), It is always obviously higher than contrasting the group efficiently treating the group; The fully recovering rate does not have significance difference (p> 0. 05).3. Two groups of patients treat the symptom after 2, 4, 6 weeks with treating the symptom is compared, examined by t, there is a significance difference (p<0. 05).4. Two groups of patient' s symptom curative effect are compared, is dealt with by statistics, the always efficient and clinical fully recovering rate has significance difference (p<0. 05), It is obviously higher than contrasting the group treating a group of always efficient and clinical fully recovering rate.5. Examine by X2, treat group person who recur and contrast group compare have significance difference (p<0. 01), It is obviously lower than contrasting the group treating a group of recuring rate, so the long-term curative effect of treating the group is obviously superior to contrasting the group.6. Examine by X2, treat group side reaction rate and contrast group compare have significance difference (p<0. 05),It is obviously smaller than contrasting the group treating group's side effect, so it is obviously superior to contrasting the group treating group's security.Conclusion:The result ind... |
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