The Study Of The Effects Of Curcumin On Metabolism Of Free Radical And Some Biochemical Indices In The Trained-indurance Rat

Many studies show that exercise can cause body to produce lots of free radicals that will attack cellular membrane system and result in the damage of structure and the malfunction of cells. Curcumin is a kind of the efficient, non -poisnous and natural antioxidant. The study that is related to the antioxidic function of Curcumin has been progressing of made pleasure researching achievements in many fields such as foodstuff, medocome, cosmetology, etc. The purpose of this study is to investigate the effects of Curcumin on growth and development, free- radical- defense system, exercise performance and concentrations of RBCM, put up some reference for explortion of Curcumin in the field of the exercise medicine and the development related to Curcumin of sports food and beverage.This studie's objects are SD rats ( ) ,The exercise models were set up by progressing intensity endurance training,The coefficient of the heart ,me indices of the liver, spleen, thymas gland were tested to investigate the effect of curcrmin on the growth and development of the athletic rat. The activity of SOD - CAI\ GSH-Px and the content of MDA were measured that reflect the status of free- radical-defense system. It was measured that some indices in the blood which reflect the metabolism of protein and performance of the aerobic exercise.The results show: 1) Curcumin can increase the indices of organs and don't affect badly the growth and development of the rat. 2) The Hb content lightly decreases in the rals after the intensity endurance training, while Curcrmin can improve this phenomenon and make the Hb content increase remakedly, which proves that Curcumin can increase the perfomance of the aerobic exercise.3)The activity of ALT , AST, LDH, Ck and the content of LDL. BUN in the serum are lower singnifcantly in Curcumin groups than in control groups .The content of Cr and HDL in the serum is higher evidently in Curcumin groups than in control groups. These results present that Curcumin can reduce destroy of the tissues and cells caused by the intensity endurance exercise such as the liver, myocardium, and so on. 4) The concentrations of the blood - glucose and glycose in liver and myocardium are higher prominently-in Curcumin guoups than control ones .It is infered that Curcumin can raise the glycoexis in the rat body.provide thi energy to the tissues of central neuronsystem, the muscle, the red cell, etc, delay the the central and peripheral fatigue and promote performance of the exercise.5) Curcumin can improve ATPase activity in intensive endurance rats which suggest Curcumin has important significance to remain osmotic Pressure balancemand crossing membrance potential. 6) Curcumin indicates the prominent performance of antioxidation and clearing the free radicals in all the tissues of the heart, liver, kidney , brain and muscle. Then the abilities of its antioxidation are different in the different tissues in no uniform conditions, and its effect on the activity of different the antioxidic enzyme is different in the same tissue in the same conditions.The conclusion: Curcumin has the strong actions on enhancing antioxidant, clearing the free radicals, It can modify the some bad effects of endurance exercise on the body and promote the capability of exercise.