The Effects Of Exercise On Serum Adiponectin And Leptin Level In Obese Postmenopausal Women

Objective: Adiponectin and leptin are circulating hormone secreted by adipose tissue. Through correlation study, we assessed the major factors regulating adiponectin and leptin levels, and also study the influence of exercise training on adiponectin and leptin levels in postmenopausal obese women (52.5±3.10 yrs). Methods: A correlation study was performed before exercise experiment. Then obese subjects were separated into three groups (aerobic exercise group [AER], aerobic and resistance exercise group [AER+RES], control group [CON]). AER underwent an 24-week training program (three times per week, 70min endurance exercise at 60%～70% HRmax intensity). The program of AER+RES was similar to AER, but went through resistance exercise 20min in base section of every exercise trail.Result: Prior to intervention, adiponectin levels were significantly correlated with BMI, WHR, COS(FPG), LN(FINS), LN(LEP), TG, LG10(VLDL-C), LN(HOMA), weight, waist, FM, %F, and leptin levels were significantly correlated with BMI, WHR , LN(FINS) , LN(LEP) , TG , HDL-C , LG10(VLDL-C), apoB , apoA1/apoB, waist, F1M, %F. Stepwise multiple regression analysis revealed that LG10(VLDL-C); COS (FPG) and waist was an predictor of basal adiponectin levels , and %F,apoB and WHR was an predictor of basal leptin levels. In early obesity, adiponectin and leptin can be worsened , along with the changed of body component, fasting plasm glucose and lipid accumulation. After intervention, both group were significantly reduction in FM, %F,weight, WHR,FPG and TG, while HDL-C had significantly increased.AER exhibited significant in leptin, while AER+RES did not show the change. Insulin and HOMA-IR were changed in both groups. The control group exhibited no significant change in any variables. Although adiponectin levels were unchanged in the three groups, a significant negativecorrelation between delta %F, delta WHR and delta FPG was observed. Futhermore, if compare the degree of delta weight, we fought a significant increased in adiponectin between the group of delta weight higher (=3kg) than delta weight lower(=0kg), delta %F, delta WHR and delta weight were significant negative correlation with delta leptin.Conclusion: These findings indicate that adiponectin plasma levels are reduced and leptin are increased with obesity. Exercise training improves insulin sensitivity, but no significant effects of exercise training on plasma adiponectin. Adiponectin is not the necessary condition of exercise-induced insulin sensitivity improvement. Perhaps, a greater amount of body weight loss is necessary to induce an increase in adiponectin levels. For increasing the adiponectin level, improvement of the body composition of postmenopausal obese women is more important than the way training is performed.