Change Of CTnI, CK-MB And TNF-α In The Overtraining Rats And The Interventional Effects Of Salvia Miltiorrhiza Compound

Objective The purpose of this study was to investigate the change of cTnI, CK-MB, TNF-αin the overtraining rats and to investigate the interventional effects of salvia miltiorrhiza compound. In order to provide the reference basis for constituting scientific training schedule and effective prevention measures.Methods Male Sprague-Dawley rats were randomly divided into group C, the control group; group NS, the normal swimming group; group O,the overtraining group; group OSM, the overtraining group which were administrated salvia miltiorrhiza compound. There were twelve rats in each group.Results (1) The expression of serum cTnI, CK-MB and TNF—αincreased significantly in the group O when the training over and 24 hour after the training as compared with control group and normal swimming group(P＜0.05 or P＜0.01). (2) The expression of serum cTnI, CK-MB and TNF—αincreased significantly in the group OSM when the training over and 24 hour after the training as compared with control group and normal swimming group, but it decreased significantly as compared with group O(P＜0.05). (3) There was a relation in cTnI and TNF—αin group O and OSM(P＜0.05). There was a relation in CK-MB and TNF—αin group O and OSM(P＜0.05). (4) Electron microscope showed that the pathological changes of myocardial tissue were serious in the group O and OSM as compared with control group and normal swimming group when the training over and 24 hour after the training.And group OSM were more slight than group O.Conclusion (1)Long overtraining results in myocardial injury. (2) YNF—αparticipates in the forming and progress of overtrianig-mediated myocardial injury. (3) Salvia miltiorrhiza compound can effectively decrease overtrianig-mediated myocardial injury degree, the mechanism of which is connected to the decrease of creating and releasing of inflammation factor.