Development Of Noval Biomedical Polyurethane And Its Application In Liquid Bandage Materials

A series of alcohol-soluble polyurethanes(PUs) and PU matrix liquid bandage materials were well-tailored and prepared based on design ideas of traditional Chinese medicine liquid bandages and their formulation optimization. The matrix polyurethane resin was prepared by using several main raw chemicals, like the polyether glycol (PPG), the isophorone diisocyanate (IPDI), the combination of BDO and DMBA in different molar ratios, and ethanol as a termination agent and the solvent.The structures and properties of the polyurethane samples were well studied by Fourier transform infrared spectroscopy (FTIR), thermogravimetry analysis (TGA), differential scanning calorimetry (DSC), etc. The effect factors like types and proportions of reactants on performance of final PU samples were highlighted in this thesis, mainly covering mechanical properties, the ability of film formation, solubility in ethanol, drug sustained-release performance, and so on.The following aspects were roughly concluded for the potential biomedical PU based liquid bandage materials.1. The raw materil system, mainly including PPG1000/IPDI/DMBA/BDO, was screened and optimized to meet the requirements of biomedical liquid bandages.2. The matrix resin was successfully produced via a cominational using the chain extenders, which could almost meet requirements like tensile strength, elongation at break, peel strength, water absorption and water vapor transmission rate. The best overall performance of the polyurethane material could be achieved with an optimal molar ratio of several key raw materials (PPG1000:BDO:DMBA=0.2:0.45:0.05) and with a solid content of70%, which showed a tensile strength of6.28MPa, a peel strength of0.41N/mm, a water absorption of5.49%, and a water vapor transmission rate of2001gm-2day-1.3. The PU based liquid bandage materials prepared in this study exhibited excellent drug compatibility and sustained-release performance, which laid a good foundation for the future innovative development and industrialization of noval liquid bandages with traditional Chinese medicines.