Porphyrin 5 - Fluorouracil Compound Synthesis And Structural Characterization

5-Fluorouracil is a kind of popular antimetabolic drug used in clinic. It has the similar structure with Uralic, which is necessary to the cancer cell. It contents with Uralic in the same enzyme system, block the metabolic link, impeds the synthesis of DNA, and then prohibits the propagation of the cancer cells .As s kind of antitumor drug, 5-Fluorouracil have inhibition effects on many kinds of cancer, but it also seriously hurts the normal cells while it kills the cancer cells.In order to improve the target activity of anticancer medicine and reduce untoward effects, the effective drug is expected with high selectivity, which mean it can distinguish target cell from normal cell properly. Because of their distinctive structure porphyrin has special biologically activity. They can be taken up and retained by tumor tissue selectively. With the appropriate light, they can produce fluorescence and kill the cancer cell. So as the tumor localization and therapy, the research on the use of porphyrin has caused great interests of chemists, medicals and biologists.So that in order to decrease the toxicity and improve the effect of 5-Fluorouracil, porphyrin with different substituted groups (-OCH3, -OH, -Cl) and 5-Fluorouracil have been linked up by different carbon chains (C2, C3, C4). We accepts these compounds can reach tumor tissue and collect and kill cancer directly .so as to improve the curative effect.In this paper, we synthesized fifteen porphyrin-5-Fluorouracil compounds. UV, IR, 1HNMR and MS have characterized these fifteen porphyrin-5-Fluorouracil compounds.