Synthesis And Structure Of The Pyrimidinone Sulfonic Acid And Its Complexes

3,4-dihydropyrimidin-2(1H)-ones exhibit promising activities as calcium channel blockers, antihypertensive agents, 1a-antagonists and anticancer. derivatives of some marine alkaloids, which have 2-amino-1,4-dihydropyrimidinone-5-carboxylate core, exhibit a wide spectrum of biological effects including antifungal, antiviral, anticancer, antibacterial, anti-inflammatory and antihypertensive effects. Because of their water-soluble is very bad, affect their drug utilization and effectual time.In this paper, synthesis of 3,4-dihydropyrimidin-2(1H)-ones used in the synthesis of a new method - ethanol thermal method, this method is simple, to save solvents, easy purification. Synthesize 10 kinds of 3,4-dihydropyrimidin-2(1H)-ones, we obtained 4 crystals using ethanol thermal method.Sulfonation of the use of 3,4-dihydropyrimidin-2(1H)-ones to carry out modification, the 10 kinds of new compounds 5a-5j, without affecting the 3,4-dihydropyrimidin-2(1H)-ones activity frame, at the same time, enhance their water-soluble.Select one of 3,4-dihydropyrimidin-2(1H)-ones sulfonate acid as a ligand, obtain three coordition compounds which have not been reported.In coordination compound 1, Complexes of Mn²⁺ with a ligand on the four oxygen atoms and two water molecules on the formation of the oxygen atoms of the hexa-coordinate octahedral structure, through the bridging ligand role in the formation of layered structure, Mn2+ in a plane, the inorganic intermediate layer in the organic layer, the aromatic ring parallel to each other. In coordination compound 2, Sm³⁺ and from three sulfonate oxygen atoms, three carbonyl oxygen atoms on the ligands and two water molecules form two inverted the pentahedral, through the ligand and metal chelate, as well as extending the role of hydrogen bonds, forming a three-dimensional network-like supramolecular structure.In coordination compound 3, Ca²⁺ and 4 from two of the six ligands coordinate oxygen atoms to form octahedral configuration, through the chelating ligand and the bridging role in the formation of the layered structure of two-dimensional...