| Objective: To investigate the clinical and endoscopic characteristics of non-steroidal anti-inflammatory drugs(NSAIDs)associated gastrointestinal mucosa damage, the relationship between NSAIDs and peptic ulcer hemorrhage. Methods: All peptic ulcers(PU) inpatients were diagnosed by endoscopy in our hospital digestive system department from January 2007 to July 2009 were collected(except complex ulcer). Gastric carcinoma was excluded by pathologic examination.Age, gender, clinical manifestations, history of peptic ulcer, cardi-cerebrovascular disease and endoscopic characteristics were included. According to the history of taking NSAIDs or not during 7 days before hospitalization. the Patients were divided into two groups. The risk factors of peptic ulcer hemorrhage were analyzed by single factor and multifactor. Results: Of the 205 PU cases, including 150 (73.2%) male and 55 (26.8%) female patients. The mean age was (50.32±17.49) years, bleeding occurred in 87 (42.4%) cases of PU. There was significant difference between NSAIDs group and no NSAIDs group in age, endoscopic characteristics, ulcer number, history of cardi-cerebrovascular disease and GI bleeding(P<0.01)49.2% in NSAIDs group applied NSAIDs to treat cardi-cerebrovascular disease. The most frequently used NSAIDs drug was aspirin(32.2%). Univariate analysis identified 5 statistically significant variables, including aged 60 years or older,history of cardi-cerebrovascular disease and GI bleeding,ulcer number and NSAIDs use(P<0.01). Logistic stepwise regression analysis showed that aged 60 years or older, history of cardi-cerebrovascular disease and GI bleeding, H.pylori infection, NSAIDs use were independent risk factors of Peptic ulcer hemorrhage. Conclusions:Gastrointestinal symptoms secondary to NSAID use is asymptomatic aged 60 years or older, H.pylori infection, NSAIDs use, history of GI bleeding and cardi-cerebrovascular disease were associated with an increased risk of Peptic ulcer hemorrhage. |
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