Quercetin Derivatives And Antitumor Activity Of Research

The recent pharmacologica] studies on the actions of quercetin, a naturally occurring favonol, were reviewed in this dissertation. We selected quercetin as a lead-compound for structural modification according to characteiistics of its chemical structure and pharmaceutical activities. The pilot study of the anti-tumor property was canied out by S180 method.8 derivatives of 4?alkylaminoalkoxyquercetin and 5 derivatives of7-amidoalkoxyquercetin were synthesized by semi-syntheses and the structures were characterized by spectral analyses (慔-NMR and UV). These 13 compounds have not been reported in literature. Influence of chemical shifts of protons in flavon moiety of skdeton by the different group substitute was illustrated.The results of the anti-cancer experiment on rats showed that most of derivatives and quercetin have no activities. In order to observe the anti-tumor effects of target compounds significantly, the dosage and the route of administration should be improved. Further more, the in vitro screening models and the chemoprevention effects of quercdin should be considered.