Study Of. The System Chuanwu Kusnezoffii Compatibility Peony Root Synergies The Mechanism

Objective: Researching the effect of analgesia, anti-inflammatory and immunoregulation can be increasing by the compatibility about preparemonkshd moter root, prepared kusnezoff monkshood root and white peony root. And the experimentation reveals the part mechanism of action of the effect.Methods: Proved the effect of analgesia, anti-inflammatory and immunoregulation of preparemonkshd moter root and prepared kusnezoff monkshood root can be increasing by the compatibility about preparemonkshd moter root, prepared kusnezoff monkshood root amd white peony root by using the threshold for pain of mice angulate their bodies, mice licking their feet and the weight of xylene mice'ears. Established the Bi-Zheng of male SD rat model in traditional Chinese medicine and revealed the part mechanism of action of the effect by detection a series of indexes, eg. inflammatory excitatory transmitter(PGE2), free radical(NO), rheumatoid factor(IgG) and cell factor(IL-1 β , TNF- α , IL-6), monoamine transmitter(5-Hydroxytryptophan, dopamine, norepinephrine, 5-hydroxy indole acetic acid).Results: 1.The compatibility about preparemonkshd moter root, prepared kusnezoff monkshood root and white peony root can increase the threshold for pain of the chemical stimulus, thermal stimulus and the feet of Bi-Zheng rat.They can restrain the weight of xylene mice'ears and the volume of Bi-Zheng rats'feet. They can rectification the pathological change of Bi-Zheng rat immunizing organs.2.The compatibility about preparemonkshd moter root, prepared kusnezoff monkshood root and white peony root can increase PGE₂ of blood plasm, NO of blood serum, cell factor(IL-1 β , TNF- α , IL-6) of blood serum and the contents of Bi-Zheng rat monoamine transmitter of brain tissue...