Compound Epimedium Oral Liquid Anti-aging Pharmacodynamic Study

Background and purpose: To acquire the anti-ageing phannacodynamical results of herbal composition of aceranthus sagittatus S.et Z.Methods: Summarizing the study base and background material, including Traditional Chinese Medicine theory and modern medicine about ageing mechanism; combining TCM and modern technology to perform the experimental designing systematically, the experimental observation content include: serum superoxide dismutases (SOD) activity of elder mice, malondialdehyde (MDA) content, lipofuscin and SOD activity of ageing rats brain and serum induced by D- galactosyl; glutathion peroxidase (GSH-Px); serum-monoamine oxidase (MAO); englobement function of endothelial system; erythrocytolysin antibody generation of mice; immune organ weight of mice; anti-fatigue and counter-hypoxia ability of ageing mice.Results and conclusions: The herbal composition of aceranthus sagittatus S.et Z. has anti-aging effect which is related to such mechanism as follows: enhancing the SOD and GSH-Px activity, inhibiting the MAO, improving the capability of free radical scavenging, decreasing the MDA and lipofuscin level, as well as the formation and deposition of lipofuscin ceroid; increasing nonspecific immunity function, so enhancing the ability of englobement of reticuloendothelial system; increasing the humoral immunity, as a result, increasing the level of erythrocytolysin antibody; such immune organs as thoracic gland and spleen weight increasing; All above experimental index might be related to anti-fatigue and counter-hypoxia ability of the herbal composition of aceranthus sagittatus S.et Z. These results improve the scientific experimental background for the herbal composition of aceranthus sagittatus S.et Z, which can be widespread clinical application in the future.