Angongniuhuang Pill Containing Artificial Musk On Experimental Cerebral Ischemia And Hypoxia And The Protective Effect Of Endotoxin Shock

Angong　　Niuhuang　Wan,which　is　from　Treatise　on　Differetiation　and　Treatment　of　Epidemic　Febrile　Diseases　writtened　by　Wu　Tang　in　the　QIN　Dynasty,　　is　consist　of　Calculus　Bovis,Cornu　　Rhinocorotics,Moschus,Margarita,Cinnabaris,Realgar,Rhizoma　　Coptidis,Radix　　Scutellarise,　Fructus　　Gardeniae,Radix　Curcumae,Borneolum　　Syntheticum.　　It　　has　functions　of　clearing　　away　heat　　and　toxic　material　and　　eliminating　　phlegm　for　resuscitation,　which　can　indicate　high　fever　　and　　delirium　due　to　invasion　of　　pericardium　　by　pathogenic　heat　and　retention　of　heat　and　phlegm　within.　　Angong　　Niuhuang　　Wan　can　cure　various　acute　cerebrovascular　diseases　with　good　effectiveness　and　light　　after-effect,　which　is　the　main　Chinese　　patent　medicine　of　treating　　pyrexia　　with　delirium　and　stroke.　　But　because　the　components　of　　Moschus　　is　from　the　mild　　Moschus,　the　Moschus　resources　is　deficient,　the　price　of　the　Moschus　is　high,　　which　is　critical　affect　the　clinical　application.　　The　artificial　Moschus　　has　　the　same　　of　　efficacy　in　clinical　with　natural　Moschus,so　the　use　of　artificial　Moschus　instead　of　　natural　Moschus　in　　Angong　　Niuhuang　　Wan　is　not　only　in　require　of　traditional　medical　clinical,but　also　can　protect　the　resource　of　the　mild　Moschus,which　is　in　person　of　the　modernization　of　traditional　medical.　Cerebrovascular　disease　is　common　disease　of　nervous　system,which　　morbidity,mortality　and　disability　is　high.　The　　important　pathologial　base　of　stroke　is　cerebral　edema　and　hernia,　　which　can　cause　a　series　of　　biochemical　disturbance,　such　as　energe　equilibrium,electrolyte　balance,enzyme　system　function,oxygen　free　radical　　and　　nerve　transmitter　content　and　fuction　disturbance　　and　so　on.　　Tranditional　Chinese　Medicine　take　the　view　that　　the　cause　of　　stroke　is　deficiency　of　　liver-yin　and　kidney-yin,　　and　the　symptoms　of　stroke　is　consist　in　wind,fire,phlegm　and　breathe,which　can　influence　each　other　in　the　course　of　stroke.　So　Angong　Niuhuang　Wan　can　remove　heat　from　the　heart　to　resuscitate　and　　protect　　brain　　tissues　in　order　to　awake　the　patients.　　Our　　study　was　designed　to　research　the　protective　effect　of　Angong　Niuhuang　Wan　containing　artificial　moschus　on　experimental　cerebral　Ischemia　in　rat,the　hypoxia　mice　and　the　endotoxin　shock　mice,so　that　it　can provide　the　　experiment　proof　for　Angong　Niuhuang　Wan　containing　　artificial　　Moschus　instead　of　natural　Moschus　　of　cureing　　ischemic　stroke　in　clinical.The　main　results　are　as　follows.　1 Protective　　effect　of　　Angong　Niuhuang　Wan　containing　artificial　moschus　on　experimental　cerebral　Ischemia　in　rat.　After　middle　cerebral　artery　thrombosis　(MCAT)　in　rats,　　brain　infarction　and...