Erigeron Injection Of Early Diabetic Nephropathy In Patients With Urinary Albumin

ObjectiveTo observe the therapeutic effects of Dengzhanxixin injection on micro albuminuria in patients with early diabetic nephropathy(DN),exploring the advantage and feasibility in combination therapy with traditional Chinese medicine and western medicine. Methods1 Sixty patients with early diabetic nephropathy ,who were Qi-Yin deficienc y or Qi-Stagnation and Blood-Stasis,were randomly divided into the treatm ent group(30 cases) and the control group(30 cases)by turn. There were no difference in urinary albumin excretion ration, age, and so on,between the two groups (P>0.05).2 Control group were mostly given the basical therapeuty,includinghealth education,exercise,controlling diet,perfect low protein d-iet, controlling salt, controlling plasma glucose with Insulin or oral drugs to aim at fast plasma glucose(FPG) less than 7.0mmol/Land plasma glucose of 2 hours after diet less than 10.0 mmol/L,controlling blood pressure ,exclude angiotensin converting enzyme inhibitor(ACEI) or angiotonin receptor blocker(ARB). But the patients in treatment group also received Dengzhanxiyin injection 30ml combined with 0.9% sodium chloride 250ml iv, gutta, qd. Both groups were treated for 2 weeks.3 The symptoms and signs of patients in two groups were observed before and after the treatment,including thirsty,fatigue,et al. The ranked quantification chart of symptoms was filled. Therapeutic effects of two groups was compared by coping with satistic.4 The parameters of such as urinary albumin excretion rate (UAER),total cholesterol(TC),triglyceride(TG),urinary β₂-MG, NAG,FDP,FPG,hemorrheolo-gy indices, mean arterial pressure(MAP) were tested and compared in two groups before and after the treatment.5 Comparison was done between Qi-Yin deficiency type and Qi-Stagnation and Blood-Stasis type to observe therapeutic effects and the UAER before and after the treatment.Results1 Compared with the control group,UAER was significantly decreased in the treated group ( 90.73 ± 11.59 ) ug/min vs ( 43.10 ± 7.15 ) ug/min ( P<0.01) .2 TC and TG were decreased in the treated group after treatment(P<0.05), but there was no remarkable discrepancy between two groups.Urine FDP was significantly decreased in the treated group than that in controll group(P<0.05).Hemorrheology indices were all improved after treatment in thetreated group,including of the whole blood high and low cutting ,fibri-nogen, however,there was noremarkable change in controll group.By cont-rasting the two groups,there was an remarkable discrepancy. But urine β₂-MG,NAG, FPG,and MAP had no significant change in the two groups before and after...