Traditional Chinese Medicine Combined With The Influence Of Different Treatment Of Iga Nephropathy End Of Clinical Observation

Immunoglobulin A nephropathy (IgAN) is the most common primary kidney disease in the world,also one of the common glomerulopathy in china.Its course and pathogenesis are undetermined,cl inical and pathologica1manifestation is too diversified,even after the40years since it disco vered.When and how to treat, are still groped ours way forward.Research shown IgAN is not a benign disease.20%patients reach the E nd Stage Renal Disease (ESRD)in every10years after clinical findings occ urred.long term follow-up, clinical endpoint and surrogate endpoint were u sed as the evaluation criterion of the treatment aboard, China has high morbidity of IgAN,but short in the developing of the thera peutic schedule and the researching of long-term outcomes.Objective:Watching the pertinence between the therapeutic schedules d ifferently and the outcomes of IgAN,evaluating the curative effect of the therapeutic schedule in use by the retrospectively analyze:To Provide th e clinical evidence of investigating the ideal therapeutic schedules of IgAN.Method:Select42patients conformed the standard diagnostic of IgAN follow-up observe in the ward of Guang’anmen Hospital treat by chinese/we stern medicine. Group by the therapeutic schedules and collect and analysi s the case data. Observe Scr, albuminuria, blood pressure and symptoms of traditional Chinese medicine. Define Renal replacement therapy and doubli ng of Scr as the clinical endpoints, degraded rate of GFR and Elevated lev el of24hours urinary protein as the surrogate endpoints.Resul ts:1Hard endpoint:Have finished the observation of42patients,no oneentry the Renal replacement therapy.One’s Scr get double and end the observation,whose Scr was kept in100%-150%after a intensive treatment until the research end.2Evaluation of therapeutic effects of all:After the treatment, the level of urine protein was declined obviously, the renal function was improved obviously and liver function steadied.By the curative effeetevaluation of the traditional Chinese medicine, the coefficient of stabilization>70%,of effectuality>20%, the Chinese medicine group has the highest coefficient of effectuali ty.3Evaluation of therapeutic effects of groups:GFR of the four groups were risen.The sequence of the rate of degraded Scr from highest tolowest is: the group of chinese medicine, the group of immunosuppressor, the group of RASI, the group of glucocorticosteroid. The degradation of the level of Scr was obvious in the group of RASI, the degradation of t he level of UTP and Scr were obvious in the group of immunosuppressor.4The improvement of symptoms and urine protein is lower than the other groups.The improvement of eGFR is higher than the others in the Chinese m edicine group.5Therapeutic effects and group of pathology typing:The therapeutic effc cts of the same therapeutic schedule of different grades of Lee had no si gnificant differences. Group the cases into3groups (Ⅲ,Ⅲ-Ⅳ,ⅣV)by the grading standards of Lee. The change of the level of GFR and Scr were obvi ous.Conclusion:Four therapeutic schedules had their strong suits but impro ve albuminuria and protect the renal foundation mutually.Chinese medicine has play a important role in casing harmful effects of Western medicine protecting the renal foundation, deferring the renal failure and observin g of quality of1lfe.