Multi-body Factors ~ 1h-mrs Of Brain Glioma, The Transfer Of The Identification Of The Tumor, Brain Abscess Diagnostic Studies

Objective To evaluate the application of ~1H - MRS in differential diagnosis among gliomas, solitary metastases and cerebral abscesses. Method 26 cases of cerebral glioma, 9 cases of solitary metastases and 4 cases of cerebral bascess were collected. All cases were underwent MR spectroscopy successfully. The Cho/NAA, Cho/Cr, NAA/Cr value of enhancing region and peritumoral region were compared respectively between the gliomas and the metastases. The results were analysed statistically. The microstructure of peritumoral region was observed by means of HE staining, immunohistochemistry, electron microscope. Results The Cho/NAA of all gliomas' and metastases' enhancement region was 3.14 ± 1.61 and 2.46 and 2.46 ± 0.83, respectively; the Cho/Cr was 2.57 ± 0.93 and 2.90 ± 1.93 respectively; the NAA/Cr was 0. 96 ± 0. 53 and 1. 21 ± 0. 80 respectively. No significant difference had been found for all ratios mentioned above between two groups (P>0. 05). The Cho/NAA in peritumoral regions of the two groups was 1. 74 ± 0. 98 and 0. 98 ± 0. 23 respectively, the Cho/Cr was 1.72 = 0.51 and 1. 09 ± 0. 35 respectively. All have significant differences(P<0.05). There were characteristic spectroscopies and high signal in DWI sequence in cerebral abscess cavity. The infiltration of glioma cells were found in the light and electron microscope examination. Conclusion Combining with routine MRI scan, ~1H - MRS can differentiate the glioma, solitary and atypical cerebral abcess.