Gastric Stasis Syndrome Of P53, C-erbb-2 And Vegf Expression In Correlation Study

Objective:Through analyzing the relationship between P53, C-erbB-2, VEGF expression in gastric cancer and clinical features of gastric cancer, to provide some guidance in classifying syndrome of gastric cancer in traditional Chinese medicine, and to help accurately determine the patient condition and prognosis.Methods:By collecting surgically resected and pathologically confirmed cases of gastric cancer, get 60 cases of complete clinical data. 60 patients of gastric cancer were randomized into two groups. There were 30 patients in blood-stasis group and 30 patients in non blood-stasis group. The two groups have good comparability. To observe P53, C-erbB-2, VEGF expression in gastric cancer of the two groups, and to analyse and compare the date of the two groups by using SPSS 10.0 statistical software .Results:1 Positive rate of P53 gene expression in gastric cancer was 60%. Positive rate in blood-stasis group (73.3%) was significantly higher than that in non blood-stasis group (46.7%) (P<0.05 ).2 Positive rate of C-erbB-2 gene expression in gastric cancer was 73.3 %. Positive rate in blood-stasis group (86.7%) was significantly higher than that in non blood-stasis group (60%) (P <0.05 ) .3 Positive rate of VEGF expression in gastric cancer was75%. Positive rate in blood-stasis group (93.3%) was significantly higher than that in non blood-stasis group (56.7%) (P < 0.05 ) .4 P53 gene expression was positively correlated with the differentiation and lymphaden metastases. Positive rate of P53 gene expression was lower in well-differentiated tumors (36.8%)than that in poor-differentiated tumors (70.7%) ,and the rate was lower in cancer without lymphaden metastases (36%) than that with lymphaden metastases (74.3%). The differences have statistical significance(P <0.05). While,Positive expression of P53 was not related to patient's age, sex, tumorsize, the extension and clinical stages (P>0.05).5 C-erbB-2 gene expression was positively correlated with the extension and lymphaden metastases. Positive rate of C-erbB-2 gene expression was lower in tumors which not be infiltrating into serosa(53.6%) than that with infiltration over serosa(90.6%), and the rate was lower in cancer without lymphaden metastases (52%) than that with lymphaden metastases (88.6%). Both of them are statistically significant (P <0.05). While, Positive expression of C-erbB-2 was not related to patient's age, sex, tumorsize, differentiation and clinical stages (P>0.05).6 VEGF expression was positively correlated with the extension , lymphaden metastases and clinical stages .Positive rate of VEGF gene expression was lower in tumors which not be infiltrating into serosa(60.7%) than that with infiltration over serosa(87.5%), and the rate was lower in cancer without lymphaden metastases (56.0%) than that with lymphaden metastases (88.6%), and positive rate of VEGF gene expression was lower in clinical stage I -II gastric cancer(44.4%) than that in clinical stage III-IV gastric cancer (88.1%). All the differences have statistical significance(P <0.05). While,Positive expression of VEGF was not related to patient's age, sex, tumorsize, differentiate degree (P>0.05).Conclusion:1. P53, C-erbB-2 and VEGF Gene albumen may be the material basis of Gastric cancer of blood-stasis syndrome. 2. Detection of P53, C-erbB-2 and VEGF Gene albumen plays a supporting role in the diagnosis of Gastric cancer of blood-stasis syndrome.3. P53, C-erbB-2, VEGF gene expression could serve as indicators of the judgement of the patient's condition and prognosis .