| The paper consists two parts: literature review and experimental study.First Section: literature SummaryThere are two literature reviews. The first article introduces the therapeutic progression in the studies on the spinal cord injury (SCI) of the late years at home and abroad. It contains these major portions: TCM treatment, Western therapeutics. The second article is review on the clinical surveys and experimental surveys of the acupuncture and moxibustion on the SCI in rats..Second Section: Experimental ResearchObjective: To discuss the protective mechanism of electro acupuncture (EA) in the acute spinal cord injury (ASCI).Methods: Rats were divided into five groups stochasticly: Blank Group, Sham Operated Group, Model Group, Drug Group, EA group. The model rats were made a spinal cord contusion by using a modified Allen's method.(1) comprehensive evaluation of neural function of SCI rats by CBS .(2) detect the calcium ion content in serum and injury local tissues after injury by MTB method;.(3) detect the NO content in serum and injury local tissues after injury .Results: 48 hours after SCI,(1) Compared with the model group, The score of CBS level in EA Group and Drug group were significant differently(P<0.01).(2) Compared with the Blank Group and the Sham Operated Group, the calcium ion and NO content in serum and injury local tissues were increased significantly in the EA Group, Model Group and Drug Group. (3)The calcium ion and NO content in serum and injury local tissues of EA Group and the Drug Group decreased significantly as compared with those in Model Group (P<0.01).Conclusion: EA had protective effect on the ASCI through depressing the calcium ion and NO content. EA can retrieve calcium overload and regulate the changes of NO that was induced by SCI.. With the purpose of lucubrating the mechanism of EA , it is very important to understand the signal transduction pathway that is mediated by the calcium ion and NO after SCI . |
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