| Research purposes:Clinical trial using research, observation of plus or minus Caihushugansan joint Deanxit in the treatment of liver Yu Pi falsely tyPe of functional dyspepsia clinical efficacy, safety and clinical study of theory and two systems of their treatment mechanism.Research Methods:(1) Select the standards of the 80 cases of patients, all from March 2006 to November 2007 in Hubei Medical College Hospital in the digestive internal medicine out-patient treatment of cases, all cases are in line with Rome III diagnostic criteria, TCM for Seoul card liver Yu Pi falsely tyPe. The treatment group were divided into 40 cases, 40 cases of the control group. In the two groups in age, gender, disease, the severity of symptoms and treatment before the total score, there was no significant difference, comparability (P > 0.05).(2) Asked in detail about history so as to factors that trigger and try to eliminate, with psychological counselling to alleviate patients with abnormal emotional. Decoction of Chinese medicine treatment group to be modified caihushugansan, joint Deanxit in the oral medicine treatment. Decoction of Chinese medicine to the side of the CD from its basic components for Bupleurum, Fructus Aurantii, TGP, Cyperus rotundus, Banxia, Citrus, dangshen, Fuling, white tricks, Zhigancao, with the card plus or minus. On the 1st one, taking on the afternoon. At the same time of the Deanxit, a daily, once a day (Am taking) . Medication for eight weeks for treatment. The control group alone plus or minus Bupleurum Powder day one, the linked eight weeks for treatment. The effects of observation, respectively (symptoms and signs, etc.) and safety of (general physical examination, routine urine tests three feces, heart liver and kidney function tests, possible side effects).(3 ) After eight weeks were compared between the two groups before and after treatment symptoms total score, after the comprehensive effect of the treatment, treatment before and after the clinical symptoms integral to determine symptoms and improve the efficacy, and so on..(4) Statistical analysis: data applications SPSS12.0 statistical software for analysis. Rating information using Ridit analysis, using data count X~2 testing, measurement data used t-test.Results:1.Two groups of patients with symptoms after treatment than before treatment total score were significant differences (P <0.05); group of Chinese medicine treatment of symptoms but the total score improved significantly better than the control group (P <0.05). 2. Clinical cure of four cases, 21 cases markedly effective, effective in 12 cases, three cases invalid, and the total efficiency of 92.50 percent. The control group healed three cases, 16 cases markedly effective, effective in 14 cases, seven cases invalid, and the total efficiency of 82.50 percent. The total efficiency is better than the control group total efficiency (P <0.05).3. To improve the treatment group Weina reduction, food after abdominal distention, Wan threaten more pain and insomnia dream Dengzheng better than the control group (P <0.05); to improve symptoms such as weakness and the effect of a control group (P> 0.05).4. The two groups after treatment of gastric motility index compared with a very significant difference (P <0.01), note plus or minus Caihushugansan obvious role in the promotion of gastric motility.Conclusion:Caihushugansan Joint Deanxit in the treatment of liver Yu Pi falsely tyPe is the type of functional dyspepsia safe and effective therapy, and its mechanism may be related to the following aspects:1.Adjustment disorder neuroendocrine function: Long-term anxiety, depression and other autonomic nervous system disorder caused, thus leading to abnormal emotional, but also spleen deficiency Liver Depression-functional dyspepsia major factor. The therapy in the new deanxit western medicine for droperidol thiadiazole tons and anthracene Sijia propylamine composition of the mixture, synergies to achieve the neurotransmitter in the central nervous autonomic nervous adjustment, anti-anxiety and antidepressant effect. Shu of Chinese medicine that is not Ganqi emotional depression, with drug Bupleurum Shugan Qi, Cyperus rotundus, and other Shugan Jieyu, a calm and soothe the nerves, and so on a wide range of central inhibition.2. Increase gastric motility, and promote gastric emptying: gastrointestinal motility disorder is the main functional dyspepsia pathophysiology basis, various gastric emptying has been confirmed by the method of inspection. Patients with more spleen deficiency in the lower gastric emptying, may be related to gastrointestinal motility disorders, gastrointestinal function adjustment disorders, slow down the movement of the stomach. Bupleurum, Fructus Aurantii a fried-fried and combined, can significantly enhance the function of promoting the small intestine and gastric emptying, with the adjustment of the gastrointestinal motility two-way role, its role in the adjustment of gastrointestinal motility with atropine and cisapride Lee close. And drug use Jianpi Yiqi dangshen, fuling, Bai Zhu, common gastrointestinal adjust its role in the campaign.3. Ease gastrointestinal smooth muscle cramps, inhibiting gastric acid secretion: the digestive organs for the performance of high sensitivity to physical stimulation in discomfort, the noxious stimulation showed strong reaction. Mainly refers to gastrointestinal mucosa and smooth muscle response to outside stimuli. Functional dyspepsia patients with stomach pain perception and the volume threshold than those in healthy controls significantly lower. Dai of the central nervous system through the new regulation, inhibit synaptic membrane of 5 - serotonin reuptake role to the analgesic effect. Chinese medicine practitioners do not think that General Clauses pain, Fu-to-reduced to. Modern medical research showed that, Fructus Aurantii can significantly reduce the tension and intestinal smooth muscle spasm, licorice and TGP also has anti-inflammatory and mitigate the effects of gastrointestinal smooth muscle spasm. Patients with functional dyspepsia basis of gastric acid secretion and the gastrin-5 stimulated gastric acid secretion were higher than those in healthy people. 40 percent to 66 percent of patients with functional dyspepsia have gastrointestinal motility disorder, to slow down the removal of the acid, an increase of gastric acid on the stomach, duodenum stimulation. Modern pharmacological research licorice contains the active ingredient anti-peptic ulcer licorice FM100, the secretion of gastric juice, and promoting the secretion of gastric juice, and pepsin activity showed strong inhibitory effect.4. Regulate immune function: Although the cause of functional dyspepsia unknown, but the immune system dysfunction in the pathogenesis of the role has been recognized. Research shows that patients with functional dyspepsia due to the long digestive tract diseases resulted gastrointestinal weakened, thus leading to widespread immune dysfunction, and the ancients that the spleen was acquired this view is consistent. For example, as early as the《Huang Di Nei Jing》are mentioned in the "defense of the spleen," said Zhang,《Jinbian Chamber》: "internal injuries spleen and stomach, Bai Bing from", "Four Seasons spleen-wang from evil." The Prescriptions through the use of dangshen, white tricks, Fuling, licorice and other Yiqi Jianpi meeting, to achieve Fuzhengquxie, adjustment of yin and yang, enhance immune function in order to better improve their symptoms. |
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