| The chronic non-specificity ulcerous proctitis is an ulcerous colitis's subgroup,and the disease incidence rate is getting higher and higher.It mainly refers to a kind of rectal non-specificity chronic inflammations of the ulcerous colitis that the inflammation limits to the rectal part 10 cm within the dentate line.The main clinical presentation are as follows:intermittent diarrhoea with mucus and blood in stool, epigastric pain,mild diarrhea or constipation.If the pathological change is light,only having the intermittent rectum bleed,it often is taken for hemorrhoids hemorrhage. Sometimes CNUP does not arrange the bloody stool,only the bowel movement number of times increase,and occurs in early moming(before down flows swiftly), must arrange 2-3 times does not form soft,but is then possible is as same as the normal person in other time.Some patients display the constipation.The majority case symptoms manifest suddenly for about 6-9d,and then the inflammation abate, and then presents the proliferative change.The majority patient symptoms are very light,losing the body weight,anemia,low proteinemia,and crissum pathological changes are less,and the serious complication is rare.Because the pathological change intermittence outbreak,procrastinates repeatedly,and the individual report may have Rectal Cancer,but thought generally the cancer risk will not be higher than the normal ordinary crowd.In recent years,modern medicine related ulcerous tied the proctitis morbidity the immunology mechanism to receive the widespread attention, and obtained progresses greatly.But it still lacked of the curative effect to be remarkable and small side effect medicine.And after stopping the medicine,it is easy to recur,and the long-term medication side reaction increased.And partial stubborn patient curative effect was not ideal.So how to display the predominance of traditional Chinese medicine(TCM) and use micr-wound therapy to relieve,even cure radically the stubborn symptom of chronic diseases,are our main research directions.According to the related TCM theory and combining modern operation method,we treated CNUP 54 cases with intensive catgut embedding therapy.Objective:To observe the therapeutic effectiveness of intensive catgut embedding therapy in patients with chronic nonspecific ulcerous proctitis(CNUP),and approach mechanism of action,provide the theory basis for the clinical application,and seek for one treatment way with the Chinese medicine characteristic.Methods:We selected non-RCT method to observe the therapeutic efficacy and clinical monitoring index of treatment group and drng group systematically.The cases were divided into two groups:The first group,the clinical study on NUP by intensive catgut embedding therapy(n=33);the second group of medicine group takes orally SASP(n=20).To observate and study its treatment result and the clinical monitor target.The treatment group adopted intensive catgut embedding therapy,which based on ordinary catgut embedding therapy and augmented acupoints stimulus intensity.We selected NO-3 double strands medicinal chromic suture and its length was about 4cm, meanwhile,implanted each corresponding acupoint four times.The acupoints included:Dachangshu,Tianshu,Guanyuan,Qihai,Zhongwan,Jianli,Xiawan,Zusanli; the controlled group:Uygur Liu Fen(the sulfur nitrogen sulphur pyridine intestines dissolve the piece,produced by Shanghai three dimensional drugs manufacture Limited company,authorized document number:Country medicine accurate character H31020450,specification:0.25g/piece,60 piece of/boxes) usage amount:The oral administration,initially the dosage is 4g daily,4 doses everyday.After applying drugs 4 weeks the symptom alleviated,and then changed into the maintenance dose,2g daily.After taking medicine for another 4 weeks,the curative effect was observed.Results:1,Effects of clinical symptoms:One month after the treatment the effective rate of treatment group was 88.2%;and the controlled group was 95.0%.The controlled group was superior to the treatment group(P＜0.05),but the clinical complete remission rate of treatment group was 61.8%,while that of the controlled group was 30%.After three months:the effective rate of treatment group was 83.3%and the controlled group was 63.2%.The treatment group was superior to the controlled group(P＜0.05),the total effective rate of treatment group was 73.5%and the controlled group was 60.0%.The treatment group was superior to the controlled group(P＜0.05).Six months later:the effective rate of treatment group was 84.0%and the controlled group was 83.3%.We can't conclude the two groups have any significant differences(P＞0.05).The total effective rate of treatment group was 61.8%and the control group was 50.0%,and we also can't conclude the two groups have any significant differences(P＞0.05).We found that,from the above data, treated after one,three,six months,clinical effective and the clinical total effectiveness of treatment group were surpass or are not lower than the controlled group,and the intensive catgut embedding therapy for CNUP is efficacious device. (Note:In the clinical effectiveness's case number after removing when the previous observation the invalid case number computation namely 3,6 months later treats the group case number respectively is 30 cases,25 cases,the controlled group is 19 cases, 12 cases;in the clinical total effectiveness's case number according to the selected case number computation,namely 3,6 month latter,two group of case number still was 34 cases and 20 cases respectively).2,Clinical total integral comparison:there is no significant difference between the treatment group and the controlled group in clinical total integral after one and three months,so there is no statistical significance,while after therapy there is significant difference with the two for the total integral decreases obviously(P＜0.01);after six months,the treatment group has difference with the controlled group in the integral and the reduction of the former is superior to the later(P＜0.05).3,Clinical main symptom's integral comparison:the two groups of patients' clinical main symptom's integral all has significant difference in one month,three months and six months after treatment(P＜0.05).After one month therapy,the treatment group can obviously improve the symptoms,such as diarrhea and bloody purulent stool,so its curative effect is superior to the control group(P＜0.05),while the improvement to abdominal pain and tenesmus feeling of the two is equal(P＞ 0.05).After three months,the treatment group can significantly improve the abdominal pain,thus its effect is better(P＜0.05),but as to the improvement of diarrhea,pus and blood stool and the bearing down,they are equal(P＞0.05).Six months after treatment, the bloody stool symptom of the treatment group has improved obviously.Its effect surpasses the controlled group(P＜0.05),while to the rest three symptoms,they have no significant difference(P＞0.05).4,Enteroscope mirror image integral comparison:after one month,three months and six months,the enterscope mirror image integral of the two groups all has significant difference than that before treatment(P＜0.05).One month after the therapy, the treatment group can obviously improve the hyperemia and hydrops,so its curative effect is superior to the controlled group(P＜0.05),while the improvement to erosion and ulcer is equal(P＞0.05).After three months,the treatment group can significantly improve the mirror image of erosion and ulcer,thus its effect is better(P＜0.05),but as to the improvement of hyperemia and hydrops,they are equal(P＞0.05).Six months after treatment,the two groups' main enteroscope mirror image integral all obviously decreases(P＜0.05),but the two groups have no significant difference in the integral changes of the four enteroscope mirror images,therefore we can't conclude there's any difference in the improvement of the main enteroscope mirror image.5,ESR change:one month,three months and six months after treatment,the ESR integral of the two groups is obviously lower than that before treatment(P＜0.05),but they are no significant difference in the changes of ESR integral,thus we can't conclude that there's any difference in the improvement of ESR(P＞0.05).6,Stool routine change:the influence to the patients' WBC:one month,three months and six months after treatment,the numbers of the WBC are all obviously lower than that before treatment,but there is no significant difference in the changes of the numbers of WBC.So we can't conclude there's any difference in the improvement of WBC(P＞0.05).The influence to RBC:one month,three months and six months after treatment,the numbers of the RBC are all obviously lower than that before treatment,but there is no significant difference in the changes of the numbers of RBC,so we can't conclude that there's any difference in the improvement of RBC (P＞0.05).Conclusion:The clinical research indicated that the intensive catgut embedding therapy for CNUP was able to improve the clinical symptoms,the result of the colon scope,and enhance the immunologic function.Its curative effect function surpassed the SASP controlled group.The findings,confirmed its feasibility and usable for the intensive catgut embedding therapy to CNUP from the clinical curative effect angle. The results showed that:under the guiding of TCM and Western Medicine,through a multi-system,multi-level and multi-conditioning link to immune function,the catgut embedding therapy was actually a complex method of treatment of a variety of therapies and the integrated effects.The medical treatment to NUP improved most effectively,and it is worth of further study and promotion. |
PDF Full Text Request