Stuffy Nose Injury Spleen Experimental Study

OBJECTIVE:The theory,"spleen should be impaired by nasal obstruction",is concluded from Pro.Xiong Dajing's long-clinic experience and admitted extensively.We observe the effect of "spleen should be impaired by nasal obstruction" on absorption and digestion of rats model,meanwhile,the regulation of Jianpitongqiao decoction to this model.METHODS:Establishing rat's nasal obstruction model by artificial obstructing nasal cavity of rats,5 groups are involved which are the normal group, the modal group,the group of Jianpitongqiao decoction in low dosage,the group of Jianpitongqiao decoction in middle dosage,the group of Jianpitongqiao decoction in high dosage.After the model was established,Jianpitongqiao decoction is given to the rat by enema starting from 14th to 21st day.After treatment,general condition, weight,spleen index,GAS,MOT,trace element Zn²⁺ Cu²⁺ number of red cell,HB and the pathogenic changes of spleen and stomach were examed.RESULTS:The results are as follow:The model rats have poor general conditions,the weight of them grown slowly,spleen index is decreased,GAS and MOT are reduced in plasma,trace element Zn²⁺ Cu²⁺ are dropped while number of red cell and HB decreased,the volume of spleen and stomach minification with congestion in spleen sinus.Jianpitongqiao decoction has significant actions of control the symptoms..CONCLUSION:"Spleen should be impaired by nasal obstruction" can drop down rats index sign which related to absorption and digestion,proper dosage of Jian pi tong qiao decoction can effectively improve these cases.