Phlegm Stasis Detoxication Treatment For Hyperlipidemia And Atherosclerosis Immunomodulation Clinical Research

BackgroundAtherosclerosis (AS) is the main etipathology basis of cardiovascular and cerebrovascular diseases. The knowledge of AS has changed from a kind of metabolic disease to immunity disease, and it is thought to be a kind of chronic vascular inflammatory disease. Traditional Chinese Medicine (TCM) attributes hyperlipemia/AS to phlegm, blood stasis. Inflammatory disease is attributed to toxin. Discussing the mechanism of the effect of tcm from the point of immunity is the main research content rencently.ObjectivesStudy the changes of immunological indexes of the phlegm and blood stasis syndrome in HL/ AS patients, Research the immunity mechanism of factors and pathogenesis of the phlegm and blood stasis syndrome in HL/AS patients and discuss the mechanism of the effects of tcm.Methods21 patients were randomly divided into treatment group 1 (eliminating sputum and absorbing clots) (Erchjen Tang and red sage root) and the treatment group 2 (eliminating sputum, absorbing clots and removing toxic agents) (Erchjen Tang,red sage root and coptis). Before and after 4 weeks medication, Blood fat (CHO,TG,HDL,LDL),Hemorheology,carotid type-B ultrasonic. subpopulation of monocyte,CD163,CD36 and TLR4 were all measured.26 healthy volunteers were comparison. Subpopulation of monocyte,CD 163,CD36 and TLR4 of patients before medication and comparisons were compared. Blood fat (CHO,TG,HDL,LDL). Hemorheology. subpopulation of monocyte. CD 163 CD36 and TLR4 of two group patients were compared.Results1. The Mo2 expression level in patient is higher than that of healthy volunteer. There is a significant difference (p<0.05).2. The proportion of Monocyte Mo2 subgroup is lower than pre-treatment. The change of group 2 has a significant difference (p<0.05). The change of group 1 has not a significant difference.3. Blood fat (CHO,TG,HDL. LDL) and Hemorheology were having the tendencies of improvement, but were not having a significant differences.Conclusions1. Peripheral blood mononuclear cell subsets Mo2 of the phlegm and blood stasis syndrome in HL/AS patient higher than that of healthy. It can be conclude that cell subsets Mo2 is playing a great deal part in the accession of HL/AS.2. The medication contain removing toxic agents is better than eliminating sputum and absorbing clots at cutting down cell subsets Mo2 and adjusting the imbalance of monocyte cell subsets proportion.3. The immunological regulation of eliminating sputum absorbing clots and removing toxic agents is earlier than the improvements of blood fat and Hemorheology.