Endoscopic Suspicious Huge Malignant Ulcer Of Microcosmic Syndrome Differentiation And The Mg <sub> 7 </ Sub> Antigen Expression Controlled Study With Follow-up Pathology

Purpose:To study the value of microcosmic syndrome differentiaiion of gastricmacro-ulcer and the expression of MG-7Ag in diagnosis and instructing follow-up mucosal pathological determination in the patients with suspected malignant gastric macro-ulcer under gastroscopy.Material and method:The expression of MG-7antigen in fifty eight patients who were suspected as malignancy gastric ulcer during gastroscopy were detected by ABC immunohistochemical method.These patients were treated with traditional Chinese medicne.The re-examination of gastroscopy and the mucosal pathological determination were performed after followed up for 6 to 72 month.Results:The positive expression of MG7-Ag in type collaterals burn damaged yin (TCBDY)and type collaterals lock hot stasis(TCLHS)was l8/19 and 8/10 respectively.It was higher than that in type gastric hot(TCH)(2/14)and type gastric cold(TGC)(2/15)(P<0.01).Nineteen gastric carcinoma were finally diagnosised out of thirty cases with positive expression Of MG7-Ag(63.3%),only five gastric carcinoma were diagnosised out of twenty night cases with negative expression of MG7-Ag (17.9%)(P <0.01).Conclusion:TCBDY and TCLHS and positive expression of MG7-Ag are valuable in diagnosing potential subsequent gastric carcinoma in patients with suspected malignancy gastric ulcer under gastroscopy.It is helpful for earlier detection of gastric carcinoma if closely following-up were performed in those patients.