Helicobacter Pylori Vaca And Caga And Gastric Cancer

Objective:To evaluate the relationship of vacA genotypes of Helicobacter pylori to cagA status and clinical outcomes.Methods Totally 105 patients including 45 with chronic surface gastritis(CSG),48 with chronic atrophic gastritis(CAG), and 12 with gastric cancer (GC), who underwent gastro copy were enrolled into this study. Each patient,3 biopsy specimens from the gastric antrum were taken, one was used for rapid urease test, one for histological examination, and one for polymerase chain reaction(PCR).extracting gastric mucosa genome, to use six couple of primers, detecting HpvacA,cagA genes.Results 57 patients were positive by the rapid urease test and histological examination 54.2%(57/105) cases were infected by Helicobacter pylori.30 samples were classified as s1/m2,10 as s1/m1,5 as s2/m1,12 as s2/m2.The cagA was detected in 89%(51/57) of Hp positive cases.There were no significant differences in the genetypes of vacA,cagA among CSG,CAG and GC.Conclusion The vacAs1/m2,cagA+ were the dominant genotypes combination of Hp. A significant association was not found between H. pylori genotypes and special gastric diseases. The vacA genotypes and cagA status should not be a good marker for predicting clinical outcomes.