Correlation Between C-Reactive Protein,Microalbuminuria,Apolipoprotein And Elderly Diabetic Cerebral Infaction

Objective:To investigate the changes of C-Reactive Protein,Microalbuminuria and Apolipoprotein in elderly diabetic patients complicated with cerebral infarction.Methods:1.Objects of study:From November 2009 to April 2010 in Geriatrics of Qilu Hospital,Ninty cases were Collected.All the patients were in-patients and were divided into three groups:30 cases of old DM group with acute cerebral infarction(I group),30 cases of Non-DM elderly acute cerebral infarction(II group),30 cases of old DM group without cerebral infarction(III group).25 normal persons served as healthy controls.All the cerebral infarction patients were consistent with cerebrovascular disease diagnostic criteria;All the DM patients were consistent with diabetes mellitus diagnostic criteria.All of the subjects had no acute or chronic infection,liver dysfunction, kidney failure, cancer,autoimmune disease,chronic heart failure,acute coronary events and history of previous myocardial infarction.2. Methods of study:The levels of height,body weight,waistline,hipline be measured,body mass index,waist-to-hip ratio be calculated.Ask the course and find out the smoking history,test blood pressure.Fasting elbow venous blood were collected to measure fasting blood glouse(FBG),glycated hemoglobin(HbA1C),total cholesterol(TC),triglycerides(TG),high density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C), apolipoprotein A-I (ApoA-I),apolipoprotein B (ApoB) and high-sensitivity C-reactive protein. Morning urine specimens was leaved to detect Microalbuminuria (MAU). 3. Statistical analysis:All data were statistically dealled by SPSS 10.0 package.Measurement data of normal distribution was showed by x±s;the mean of normal distribution between the two groups was compared using the t test number,test of significance using two-sided test,P<0.05 was considered as statistically significant.Correlation analysis of two variables using non-parametric Spearman rank correlation test. And the above-mentioned indicators were analyzed by logistic regression analysis.Results:1.Comparison of general information:age, sex, smoking, BMI and other factors of each group was tested by statistical test, there was no significant difference between any two (P> 0.O5) and be comparable.2.hs-CRP values in age,gender ratio,smoking,BMI and other factors were no statistically significant difference.The level of hs-CRP in I II III groups was higher than that of IV group(P<0.01,.P<0.05),near regression analysis indicated that hs-CRP was no correlation with TC,LDL-C and ApoB,but was positive correlation with TG,MAU(P<0.05),and was significantly negative correlation with HDL-C,ApoA-I(P<0.01).3.The level of MAU in I II III groups was much higher than that of IV group(P<0.01),the level of MAU in I groups was higher than that ofⅡⅢgroup(P<0.01),and the level of MAU inⅡgroups was lower than that of III group(P<0.01).Simple correlation analysis indicated that MAU was positive correlation with FBG and HbA1C,but was no correlation with TC,TG,HDL-C andLDL-C.4.The levels of TC,TG,LDL-C,ApoB were higher than that of IV group(P<0.01), the levels of HDL-C,ApoA-I were lower than that of IV group(P<0.01),and the level of TC,TG,LDL-C and ApoB in I groups were higher than that ofⅡⅢgroup(P<0.01,P<0.05), the level of HDL-C,ApoA-I in I groups were lower than that ofⅡⅢgroup(P<0.01,P<0.05), the level of TG,LDL-C in II groups were lower than that of III group(P<0.05).Conclusions:1.The concentrations of hs-CRP is closely related to the risk of diabetes cerebral infarction. 2. The levels of MAU is closely related to the occurred of cerebral vascular events in diabetes.3.The increased levels of TC,TG,LDL-C,ApoB and the reduced levels of HDL-C,ApoA-I are the risk factors to diabetes mellitus with cerebral vascular disease.Significance:This issue further clarifies the relationship between C-reactive protein, Microalbuminuria,Apolipoprotein and cerebral infarction in elderly diabetic patients, that has important clinical significance and applications Value to the effective prevention of cerebral infarction and deseasing cerebral vascular end point in patients with diabetes.