The Clinical Research Of Functional Mechanism Of Shenmai Injection On Myocardial With Ischemia Reperfusion Injury

Objective:This study is to observe the effects of Shenmai Injection on myocardial with ischemia reperfusion injury and the changes of serum SOD,MDA,IL-6,TNF-a,NO, and to discuss the functional mechanism of SMI, in order to provide theoretical basis for clinical application.Methods:During 2010.5-12, the patients who were admitted for acute coronary syndrome and were successfully revascularized by PCI were randomized into Shenmai injection group(n=20), Creatine Phospate group(n=20), Blank control group(n=20). The patients in each group were received anticoagulation,antiaggregatory,statins,B-block,ACEI,isosorbide mononitrate et al according their condition. Blank control group:The patients were given coronary angiography, according the results, the lesion coronary were given extension by balloon and/or stent implanted. The related coronary arteries were successfully revascularized and the IR flow≥TIMI 3 grade flow. Shenmai injection group:The patients were given SMI 40ml intravenous guttae on the basis of the patiens in blank control group. Creatine Phospate group:The patients were given Creatine Phospate 1g intravenous guttae on the basis of the patiens in blank control group. The activity of serum superoxide dismutase(SOD),interleukin-6 (IL-6),tumor necrosis factor a (TNF-a) and the contentration of malondialdehyde (MDA),nitric oxide (NO) were assayed. All of them would be compared in order to see whether they had the dramatical difference.Results:There are no significant differences of the activity of SOD,IL-6,TNF-a and the contention of MDA,NO among these groups preoperative. After operation, The activity of SOD,NO in the Blank control group was lower than preoperative, the contention of MDA,IL-6,TNF-a was higher than preoperative, have significant differences through the statistical analysis(P<0.05). But patients in the Shenmai group and Creatine Phospate group showed the opposite result, compared with the patients in Blank control group, the result show significant differences through the statistical analysis(P<0.05).Conclusion:SMI can get rid of OFR and prevent cell lipid peroxidation, improve the vascular endotheial cell function, relieve the inflammatory cell infiltrate, improve the myocardium microcirculation, SO SMI have the function of protection of MIRI.