ChaiHu HeWei Decoction United Trimebutine Maleate Treatment Of Functional Dyspepsia Clinical Observation (Liver-against-stomach Syndrome)

[objective]The purpose of this study self ChaiHu He Wei decoction associate with trimebutine maleate treatment of functional dyspepsia (liver-against-stomach syndrome) than trimebutine maleate treatment of functional dyspepsia (liver-against-stomach syndrome) have advantages by clinical efficacy, traditional Chinese medicine symptom points before and after the project, the incidence of adverse reactions after the project, the recurrence rate and other areas.[Methods]1. Select the Hubei Provincial Chinese Medicine Hospital outpatient and inpatient digested targeting criteria included 78 cases of functional dyspepsia, traditional Chinese medicine for liver-against-stomach patients during June 2009 to October 2010. Through statistical software, All patients were randomly divided into experimental and control group of 39 cases. Through statistical analysis, Two groups of patients in gender, age,, disease duration, disease severity, the symptoms of pre-treatment score and Chinese medicine symptom total score and so on statistical significant differences in comparable (P> 0.05)2. Both groups were orally dispersible tablets Trimebutine maleate (Trade name Niweifu) per 0.1g, three times a day, taking half an hour before meals. The experimental group on the basis of the control group taking ChaiHu He Wei Decoction, decoction juice 200ml, twice after meals, the basic side as follows:ChaiHu lOg, ZhiShi lOg, ChiShao lOg, BaiShao lOg, Yun Ling 10g, Bai Zhu 15g, BanXia lOg, ChenPi lOg, Xiang Fu 10g, YuJin lOg, TangShen lOg, JiaoSanXian lOg, ZhiGanCao 6g. The two groups are one course of treatment for four weeks. Informed patients not taking treatment of functional dyspepsia-related drugs throughout the course of treatment, and told patients light diet, to avoid raw foods, to avoid spicy foods, to avoid greasy and irritating foods, and so on. Both groups monitoring patients with vital signs before and after the project, and make general medical examination, such as, blood,urine,stools tests and the fuction tests of hearts liver and kidney.3. Statistical analysis:All data were analyzed using statistical software SPSS 16.0. ranked data on the use of Wlilcoxon Mann-Whitney test measurement data using T-test, classification data using X2 test.[Results]1. The experimental group, there is clinical recovery in 6 cases, with markedly effective in 20 cases, with effective in 8 cases, with ineffective in 5 case, the total efficiency of 87%, The control group, there is clinical cure in 4 cases, with markedly effective in 9 cases, with effective in 18 cases, with ineffective in 8 case, the total efficiency of 79%. Through the statistical analysis Comprehensive clinical efficacy of the two groups had significant differences. The clinical efficacy of experimental group better than the control group.2.After the project, the experimental group's TCM symptom total score was 7.15±4.49, control group was 11.28±6.40, Through the statistical analysis, two groups of traditional Chinese medicine symptom total score had significant differences.3. In the experimental group, the symptoms of abdominal distention, gasgralgia nausea, epigastric discomfort, hypochondriac pain, depression or irritability, belching, acid reflux, loss of appetite, vomiting, ect, were improved than control group.[Conclusion]The research discuss self ChaiHu He Wei Decoction associate with trimebutine maleate treatment of functional dyspepsia (liver-against-stomach syndrome), in improving clinical symptoms, improving efficiency, the recurrence rate are superior to western medicine alone. According to the traditional Chinese medicine theory to analyze ChaiHu He Wei Decoction, the part set of rigorous, closely linked to the treatment of Liver and stomach principle, to treat liver-against-stomach Syndrome of purposes, from modern pharmacological research and analysis, the mechanism may be as follows:1.There are two-ways to adjust the gastrointestinal; 2. To promote the secretion of digestive enzymes; 3. To protect the liver and nourish gallbladder; 4.To enhance immune function. Its treatment of functional dyspepsia with scientific theory. Consequently, ChaiHu He Wei Decoction to treat functional dyspepsia (liver-against-stomach syndrome) effectively, It deserves our in-depth study in the future.