The P14^ARF Protein Expression And Clinical Significance In Oral Squamous Cell Carcinoma Tissues

Objective The research mitotic cycle suppresses the protein (cell cycle inhibiting protein) p14ARF in the oral cavity squamose cell cancer (oral squamous cell carcinoma OSCC) organizes the expression and the significance.Materials and Methods 70 example surgeries excise or the biopsy organization, is fixed after 10% formalin, paraffin wax embedding, conventional HE dyeing and pathological diagnosis.High split up scale cancer 53 examples, low split up scale cancer 17 examples. In addition chooses 20 example oral cavity normal mucous membrane organization to make the comparison. Selects the normal oral mucosa organization and the oral cavity squamose cell cancer organizes, the specimen spot including the cheek, the tongue, the mouth bottom, the gum, has not passed through puts the chemotherapy. The application immunity histochemistry S-P method examines 70 example oral cavity squamose cell cancer to organize in the specimen the pl4ARF protein expression, simultaneously makes the comparison by 20 example oral cavity normal mucous membrane organization.Results In the normal mucosa tissue the positive expression rate of p14ARF gene protein is 90%; in the oral squamous cell carcinoma tissues it is p14ARF 38.57% (P<0.01); In oral squamous cell carcinoma tissues its expression and oral squamous cell carcinoma is closely related to the pathology classification, medium, low differentiated squamous cell carcinoma tissues of oral p14ARF gene expression obviously lower than the organization, whose high differentiation oral expression increases with the TNMstage reduction. This shows p14ARF gene inactivation in the mouth of protein occurrence and development of squamous cell carcinoma plays an important role, and the expression and oral squamous cell carcinoma staging and pathology classification, TNM stage is closely related to the higher the worse of differentiation, cancer gene albumen p14ARF lack of higher rates. Therefore, the lost of p14ARF gene may play an important role in the progress of oral squamous cell carcinoma.Conclusions The oral cavity squamose cell cancer organizes the p14ARF protein expression to have the obvious organization pathology characteristic, damps cancer gene p14ARF possibly to have the influential role in the oral cavity squamose cell cancer's progress, may take one kind of tumor tracer to use in oral cavity squamose cell cancer's clinical screening and the diagnosis.