Clinical Characteristics And Pathogenesis Of HIV Infection And HAART-related Lipid Metabolic Disorder In HIV/AIDS Patients

Objective:Clinical characteristics of HIV infection and HAART-related dyslipidemia were analysed in HIV/AIDS patients in Yunnan Dynamic blood lipid and serum oxidate stress index namely malondialdehyde (MDA) and superoxide dismutase (SOD) were observed. To explore the pathogenesis of HIV infection and HAART-related lipid metabolic disorder in HIV/AIDS patients.Methods:A total of twenty patients with HIV infection and AIDS were enrolled and treated with HAART. Fifteen normal health participants were served as control group. The patients were followed at month3,6,12after treatment and the parameters of blood lipid were measured by automatic biochemical machine. MDA and SOD were detected with ELISA method. T-cell subsets were examined by direct immunofluorescence using flow cytometry. The clinical characteristics of HIV infection and HAART-related dyslipidemia and the relationship between abnormal blood lipid and oxidate stress index were analyzed.Results:(1) Before HAART start, HIV/AIDS patients HDL was significantly lower than the health in control group (P<0.05), TG was significantly higher than the health in control group (P<0.05), and the two groups of TC and LDL did not showed significant difference (P>0.05); After HAART started, HIV/AIDS patients TC, TG, LDL after treatment were obviously higher than the before (P<0.05), and HDL did not showed significant difference (P>0.05);(2)Before HAART start, HIV/AIDS patients serum MDA, SOD were significantly higher than the health in control group (P<0.05); After HAART started, HIV/AIDS patients serum MDA after treatment was significantly higher than the before treatment (P<0.05), and serum SOD was significantly lower than before treatment (P<0.05);(3) HIV/AIDS patients TG was positively correlated with the length of infection time and serum MDA content (P<0.05); and HDL was negatively correlated with the length of infection time and serum MDA content and serum SOD content (P<0.05), and was positively correlated with CD4+T lymphocyte count (P<0.05);(4) During HAART,TG was positively correlated with serum MDA content (P<0.05); TC was positively correlated with serum MDA content (P<0.05), and was negatively correlated with serum SOD content (P<0.05), LDL was negatively correlated with serum SOD content (P<0.05);(5) Before the start of HAART treatment of HIV/AIDS patients, CD4+T lymphocyte count had a negative correlation between serum MDA, and no correlation serum levels of SOD;(6) With the extension of time of HAART, the overall trends of TG, TC, LDL and serum MDA are gradually increased, the overall trend of serum SOD is gradually reduced.Conclusion:(1) HIV infection causes patients dyslipidemia, can be expressed as high TG, low HDL hyper lipidemia; HAART prompted an infected person dyslipidemia heavier, and its transformation into mixed hyper lipidemia;(2) HIV infection/HAART cause dyslipidemia are closely related with oxidative stress;(3) Immunodeficiency caused by HIV infection and oxidative stress related, and they are the cause to HIV infection common inpatients with dyslipidemia.