| Purpose: Along with our country people's living level of more and more high, clinicalmyocardial infarction increasing incidence, and myocardial infarction mortality rates, thetrend of increased year by year, adult is the main cause of death, serious harm to the health ofour people.This study traditional Chinese medicine and red: qi and activate blood circulation,dredging decoction of myocardial infarction rats coronary angiogenesis role, confirmed andred, dredging, make the organization ischemia area of traditional Chinese medicine selfbypass, restrain ventricular remodeling, after myocardial infarction myocardial ischemia ofprotective.Methods: the application of coronary artery ligation of the left anterior descending causeacute myocardial infarction rats model, to observe and red, dredging of traditional Chinesemedicine (specific as follows: rhodiola, composed, danshen, born a fall sweet and leeches,melons, semen, GanSong, rhizoma acori tatarinowii) on myocardial infarction rats heartangiogenesis and infarction area of influence. Explore the size of traditional Chinese medicinedose after myocardial infarction rats angiogenesis and infarction area have different role.Establish rats myocardial infarction model, were given drugs, explore Chinese medicine ofischemic heart angiogenesis, infarction area of effect. Rats randomly divided into5groups:profit qi and activate blood circulation party high dosage groups (A), low dose group (B), bayafter Jackie and heparin group (C), model control group (D) and JiaShouShu group (E)5group.The complex agent and heparin (positive control group, and the negative controlrespectively by physiological saline.According to the above method for medicine group, normal raise4weeks,4weeks aftertesting infarction area, VEGF, bFGF, factorⅧ express quantity, factor Ⅷ vascular surfacedensity, observe the traditional Chinese medicine of myocardial infarction rats the influenceof ventricular remodeling.Results:. Watch four weeks after myocardial infarction detection Chinese traditionalmedicine group rats infarction area reducing, left ventricular infarction edge ascularendothelial growth factor VEGF, alkaline fibroblast growth factor bFGF, factor Ⅷexpression than the control group increased amount, infarction fringe area factorⅧ vascular surfacedensity increased also.Conclusion: Chinese medicine has the function of promoting the vascular regenerationassured curative effects, establishes the traditional Chinese medicine in the treatment ofischemic cardiovascular disease status. After myocardial infarction can significantly improvethe quality of life of patients with angina, prolong life and improve the whole level of Chinesemedicine treatment and prevention and control level. |
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