Synthesis, Structures And Biological Activity Of Salicylaldehyde And Its Derivation With Schiff Bases

Schiff bases and their transition metal complexes is an important class of compounds，whose structure and functional variability make it of important significance in not onlychemistry but also biology studies. Therefore, it is widely used in catalyst, magnetic materials,fluorescent materials, fluorescent reagents, medical and agricultural fields. The study of thesynthesis, structure and function between transition metal ions and Schiff base ligands plays avery important role in further study of its biological activity of the structure, mechanism ofaction and stability.Salicylaldehyde and its derivative Schiff base ligand contain N and O atoms, and it makesthis kind of multidentate chelate ligands with transition metal and rare earth metals all havegood coordination ability.Therefore, it causes chemical researchers taking great interest in itand also becomes a hot issue in their studies.In recent years, according to the experimental results, the structure of Salicylaldehyde andits derivative Schiff base has certain characteristics which may slow urea decomposition rateand reduce urease activity. For these characteristics, Salicylaldehyde and its derivative Schiffbase evolves a urease inhibitor of potentially important role.This paper is from the Schiff base of the classification, synthesis and characterization ofareas such as research and analysis. Synthesis of16salicylaldehyde and its derivative Schiffbase ligand,with its different transition metal salts were response, the synthesis of19newSchiff base complexes. By element analysis, IR spectra, X-ray single crystal diffraction andother methods to synthesis of complexes of. The lab has7Schiff base alkaline complexes aswell as the new synthesis of the5complexes inhibit the activity of urease test and research.The research into the following four aspects:1. Salicylaldehyde and their derivatives with different alcohol amine was synthesized in sixdifferent ligands, and separately with different transition metal salt complexes, formed of fourbinuclear Cu (II) complexes, one poly nuclear Zn (II) complexes,two double nuclear Cu(II) complexes. There are two binuclear copper is used in solvent heating method forsynthesis.2.Salicylaldehyde and their derivatives with different alcohol amine was synthesized in fivedifferent ligands, and separately with different transition metal salt complexes, formed six mononuclear complexes.one Zn (II) complexes, two Ni (II) complexes, one Co (III)complexes in which the cobalt used solvent thermal synthesis.3. Salicylaldehyde and their derivatives with different alcohol amine synthesis of ligand, andthe second transition metal Mo (VI) synthesized five novel mononuclear molybdenumcomplexes.4The laboratory for the synthesis of the six Schiff alkali transition metal complexes as well asthe new synthesis of five new complexes were inhibited urease activity determination, foundby determining: Complexes19,26has good urease inhibition activity.