The Effect Of The Ganoderma Lucidum Spores (GLS) On Liver Function And Immunological Status In HCC Patients Who Underwent Hepatectomy

ObjectiveIn China, Primary liver cancer is the second most common malignant tumor.The patients’ operation excision rate is low, postoperative recurrence rate is high,prognosis is poor. Ganoderma lucidum spores(GLS) is our traditional medicine whichcan enhance patients’ immunity and antitumor. This article’s aim is to annalys theeffect of The ganoderma lucidum Spores GLS on liver function and immunologicalstatus in HCC patients who underwent hepatectomy.MethodsThe patients in general surgery department of our hospital during november2008and december2010, who experienced hepatectomy, were randomly divided intoconventional therapy group and GLS therapy group. Compare the differences of theone week (1d,3d, and7d) of postoperative liver function, peripheral T Iymphoeytessubsets and NK cells preoperative and on day1，7and28after hepatectomy.Results1.There were obvious impairments of liver function at first day after hepatic resection in two groups. After a week of protective treatment for liver injury afterhepatectomy, the liver function of GLS treatment group was significantly improvedcomparing to that of conventional treatment group (P=0.032). Two cases inconventional treatment group were manifested with liver dysfunction, but no one inGLS treatment group. There were no significant differences in complications ofoperation (P=0.453) and side-effects of drug (P=0.874) between conventionaltreatment group and GLS treatment group.2.The proportions of CD4+and NK cells were lower and that of CD8+cells washigher in HCC patients than in healthy persons(bothP<0.05). After1day ofhepatectomy,the proportions of CD4+、CD8+and NK cells were decreased(P<0.05)compared to pretreatment values. the proportions of CD4+、NK cells afterhepatectomy in GLS treatment group were found significantly higher thanconventional treatment group (P<0.05). the proportions of CD8+cells afterhepatectomy in GLS treatment group were significantly lowwer than conventionaltreatment group (P<0.05).3. There were no significant differences in operational complications andside-effect of drug (20.0%v.13.3%, P=0.371) between two groups.Conclusion1. The GLS treatment had favourable efficacy on reducing impairment of liverfunction after hepatic resection in patients with HCC.2. The cellular immunological functions were inhibited in patients with HCC.Ganoderma lucidum Spores GLS can improve the cellular immunological functions inHCC patients who underwent hepatectomy.3. The GLS is safe and effetive.