| Objective: To study the matrix metalloproteinases-7, transformation growth factor beta1in bile duct carcinoma, and evaluated the relativity with tumor invasion and metastasis. Toprognosis provide new basis for the early detection of the bile duct carcinoma.Methods: The immunohistochemical examination of MMP-7and TGF-βwere carriedout in two groups, test group composed of25patients with bile carcinoma, and control groupwith20cases of normal bile ducts.Results:(1) The expression of MMP-7in two groups were obviously different (P <0.05).The positive rate of test group was higher than normal.(2) The research showed nosignificance of the expression of MMP-7of different groups of sex ratio, tumor site, bile ductcarcinoma, the pathological points (P>0.05); but in differentiation degree, nerve infiltratingdegree and the clinical stages showed significant difference (P <0.05).(3) The expression ofTGF-β1in two groups has significant difference (P <0.01). The test group has obviouslyhigher expression than control group.(4) The research showed no significant difference of theexpression of TGF-β1of different groups of sex ratio, tumor site, bile duct carcinoma,pathological points, differentiation, location irrelevant (P>0.05); and groups divided bynerve infiltrating degree and clinical stages, showed significant difference (P <0.05).Conclusions:(1) The positive rate of MMp-7in bile duct carcinoma was higher thancontrol group. and relative with the factors of tumor site, differentiation, nerve infiltratingdegree and the relevant clinical stage.(2) The positive rate of TGF-β1in bile duct carcinomawas higher than normal group, and about how extensive the nerve. |
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