Radish Seed Water-soluble Alkaloids On Normal Diet Apoe-deficient Mice Blood Lipids, And Superoxide Dismutase, Malondialdehyde Experimental Research

Atherosclerosis (AS) is atherosclerotic vascular disease, a type of common, but AS is a number of common and frequently-occurring major pathological basis.Such as hypertension, coronary heart disease, diabetes.Atherosclerotic cardio-cerebral vascular diseases serious harm to human health.Has become the leading cause of death worldwide.Plasma lipid metabolism disorders in the occurrence of atherosclerosis and development play an important role.According to TCM theory, the blood lipid Valley for water and nutritious food in the thick cloud of part of the technology, proper body was necessary, too much damage was evil.Excess of its retention for those who like water, liquid poly-phlegm.Radish Seed clinical application of anti-atherosclerosis in order to draw upon Jiangqi expectorant Huazhuo role.Radish Seed To further clarify the anti-atherosclerosis effect and related mechanisms to be objective, scientific evaluation.Through the ordinary diet of apolipoprotein E (ApoE) gene knockout mice give Radish Seed water-soluble alkaloids, the following several studies.1,Radish Seed water-soluble alkaloids of the ordinary food environment ApoE-knockout mice effects of changes in blood lipids2,Radish Seed water-soluble alkaloids of the ordinary food environment ApoE knockout mice Serum superoxide dismutase (SOD) and malondialdehyde (MDA) content in.Methods: 50 1 weeks normal diet-fed 13 week old male ApoE-knockout mice were divided into five groups: model group, Radish Seed total alkaloids of high, medium and low-dose group, Wenstardin positive control group, n = 10.After 12 weeks on the administration, testing four lipids: serum total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), low density lipoprotein (LDL-C), and SOD, MDAcontent.Results:1,Radish Seed water-soluble alkaloids could reduce the normal diet conditions ApoE knockout mice Serum TC, TG, LDL-C levels, while elevated levels of HDL-C.2,Radish Seed water-soluble alkaloids to enhance the general environment, diet ApoE knockout mice Serum SOD activity and lower MDA content. Through this subject in-depth study, to further clarify Radish Seed total alkaloids of anti-atherosclerosis mechanisms and provide experimental basis for clinical application.