Correlation Between Copd Patients With Anxiety&Depression Symptoms And The Bode Index

Objective: Anxiety and depression are two of the most commonandmodifiable co-morbidities of chronic obstructive pulmonary disease (COPD)and have an independent effect on health and prognosis. FEVl%pred has beenshown to be a poor predictor of anxiety and depression. The body mass index,degree of airflow obstruction, dyspnea, and exercise capacity (BODE) index is amultidimensional assessment system which may predict health outcome inCOPD patients. The purpose of this study was to investigate the predictivevalidity of the BODE index for anxious and depressive symptoms in COPDpatients.Methods: This was a multicenter, prospective, cross-sectional study in186patients with stable COPD. Anxious and depressive symptoms were assessedusing the Hospital Anxiety and Depression Scale (HADS). The relationshipsbetween anxiety, depression and potential predictors (including the BODE index)were analyzed by a binary Logistic regression model.Results: Subjects who had anxiety and depression, walked a shortersix-minute walking distance (6MWD), had more dyspnea, a higher BODE index,and lower health-related quality of life (P <0.05). Anxiety and depression score was significantly correlated with BODE(P<0.05). The prevalence ofanxiety and depression elevated with increasing BODE stage(P <0.05). On thebasis of binary Logistic regression, the BODE index was a good andindependent predictor of anxiety and depression because it compirsed dyspneaand6MWD, which were shown to be the main determinants.Conclusion:The predictive validity of the BODE index for anxiety and depression wasdemon-strated. We propose that the BODE index should be included inassessment of COPD severity.