Diagnostic Value Of Serum GP73and AFP Detection In Primary Liver Carcinoma

OBJECTIVESTo explore the diagnostic value of serum GP73in the patient of primary liver carcinoma (PLC), discuss the diagnostic value of the joint roles of serum GP73and AFP in the diagnosis of PLC, and provide a new detection method for the diagnosis of PLC.METHODSELISA method was used to detect the serum level of GP73in144cases of PLC,50cases of hepatic cirrhosis,100cases of hepatitis,50cases of other malignant tumors,26cases of liver benign lesions,84cases of hepatitis carriers and50cases of healthy volunteers (as the controls). The electrochemical luminescence method was used to detect the serum level of AFP of the all, and the level of AFP was as a comparison.RESULTS1. The level of serum AFP and GP73in the group of PLC were significantly higher than that of hepatic cirrhosis, hepatitis, other malignant tumors, liver benign lesions, hepatitis carriers and healthy volunteers (as the controls)(168.22±1045.58vs149.81±1091.98、30.32±146.73、19.65±137.39、 30.05±147.35、28.58±143.27�'�13.98±8.74,P=0.041、0.000、0.000、0.000、0.000�'�0.000), the critical value for GP73was determined to be64.4ng/mL through the ROC curves, under the critical value the sensitivity and specificity of the GP73was83.3%and88.3%, and these were the best.2. The difference of GP73and AFP in the group of PLC was statistically significant (83.3%vs72.2%, P=0.023).3. The diagnostic sensitivity of the joint roles of serum GP73and AFP was increased to94.4%, and the specificity up to65.5%. The Sensitivity of the joint roles of the both was significantly higher than one single detection of GP73(83.3%) or AFP (72.2%).CONCLUSION1. The GP73was one of the best liver tumor markers, which had better sensitivity and specificity than AFP. The diagnostic sensitivity and specificity of the serum GP73in the diagnosis of PLC was better than AFP.2. The joint roles of serum GP73and AFP could reduce effectively the missed diagnosis and of PLC whose AFP was negative or low concentration, it could improve the detection rate and the diagnosis accuracy of PLC, it was one of the best effective diagnosis combination in tumor markers of PLC.