A Contrast Study Of Intravesical Instillation Of Anthracycline Antibiotics And Hydroxycamptothecine In Prevention Of Non-muscle-invasive Bladder Cancer Recurrence

PurposeThe aim of this study was to compare the prophylactic efficacy and safety of anthracycline antibiotics and hydroxycamptothecine (HCPT) in non-muscle-invasive bladder cancer (NMIBC).MethodsThis study enrolled a total of51patients who had be en diagnosed with NMIBC during the period from the september in2009through the december in2010at the second affiliated hospital of zhejiang university. All patients were randomly allocated to one of two treatment groups. Depend on the different drugs we used,Patients divided into two group. Group A used anthracycline antibiotics,,and group B used hydroxycamptothecine. Meantime i divided group A into two small groups (group Al and group A2) according the exact medicines. People in group A1received pirarubicin (THP)30mg/30ml, patients in group A2received epirubicin (EPI)40mg/50ml, and patients in group B received hydroxycamptothecine (HCPT)20mg/50ml, over a period of12months. ResultsThe recurrence-free rate in the anthracycline antibiotics and hydroxycamptothecine treatment groups (A and B) were similar.In the safety evaluation, the incidences of pollakiuria, pain on urination, dysuria, hematuria, and contracted bladder were not significantly different between groups A and B.ConclusionThe efficacy of anthracycline antibiotics and hydroxycamptothecine were similar in the prevention of bladder cancer recurrence.