Shenfu Injection Therapy For Patients With Septic Shock:a Prospective Controlled Study Of16Cases

Objective:To evaluate the efficacy and safety of the shenfu injection (SF) in patients with septic shockMethods:16patients with septic shock received Early goal-directed resuscitation(EGDT), antibiotics and other basic treatment were randomized to2groups:SF group (n=8) received SF and non-SF group (n=8) received placebo (NS) for6days. The blood sample were drawn respectively before and6h,12h,24h,6d after drug administration for the mesurement of lactic acid and drawn before and24h,48h after drug administration for the mesurement of TNF-a, IL-6. The The values of hemodynamics including CI, SVRI, EIVWI were mesured before and48h after drag adminstration with PiCCO. The mortality rate were observed and compared at7days,28days, as the ICU stay time.Results: 1) The lactic acid in the SF group were significantly lower than in the non-SF group12h,24h after adminstration (2.3±0.21mmol/L vs3.21±0.40mmol/L,p=0.002;1.59±0.20mmol/L vs2.91±0.3mmol/L,p=0.001).2) The TNF-a, IL-6in the SF group were significantly lower than in the non-SF group48h after administration (58.32±9.63pg/ml vs70.24±10.12pg/ml, p=0.239;203.91±22.46pg/ml vs245.48±24.30, p=0.168).3) The CI in the SF group were significantly higher than in the non-SF group48h after adminstration (3.9±0.94L/min/m2vs3.1±0.82L/min/m2, p=0.002), and no statistical difference were found in SVRI and ELVWI.4) The mortality rate were37.5%and25%for non-SF and SF group,(p>0.05). And ICU stay time were29±13.5d and27±14.2d for non-SF and SF group,(p>0.05).Conclusion:In the septic shck patients, SF effectively reduced the lactic acid in the early time, had an inhibitory effect on plasma cytokines TNF-a and IL-6, and elevated the CI significantly.