The Examination And Significance Of Measles Virus In Pregnant Woman Veinal Blood And Newborn Navel Blood

Background：Measles is a kind of respiratory infectious diseases causedby the measles virus,and it is one of limited kinds of infectious diseases thatcould be effectively controlled via vaccination. Although the morbidity andmortality caused by measles were significantly reduced by the widely use ofmeasles vaccines,measles is still a problem of public health and still threats tothe children’s health and safety all over the world.Measles virus is singleserotype,and its heredity has been considered relatively stable.Since measleselimination was first proposed before measles vaccine was licensed in theUnited States in1962,definitions of measles elimination have evolved andprogressed from“assuming a reduction to zero of the incidence ofmeasles”to“the absence of endemic measles transmission”,and“incidence ofmeasles＜1/per million population as an operational definition”.In December2010，WHO defined measles elimination as“the absence of endemic measlestransmission in a defined geographical area（e.g.region）for≥12months underthe presence of a well performing surveillance system”,which emphasized thesignificance of well performing measles surveillance system.Measleselimination requires an objective，external verification process. It has become acommom aim of all countries on the earth.Along with the progress ofaccelerating measles control,the reported incidence of infant measles cases wasrising.If we cannot control the incidence of measles very well in infants, it willaffect our goal of eliminate measles undoubtedly.Objective：Evaluate the level of measles’IgG in healthy lying-in mothersand non-measles infants to assess their protective competence to measles. To analyze the cause and preventive strategy for increased measles incidence ininfants.Methods：We collected blood samples from122healthy lying-in mothersand their non-measles newborns，and Enzyme Linked ImmunoSorbent Assay（ELISA）was applied to detect the levels of MV IgG.Results: The positive rate of measles antibody was85.24%in122child-bearing women.There was obvious relationship between the ages ofchild-bearing women and the positive rate of measles antibody.The positiverate of29-34years old was highest and it was lowest over35years.Thepositive rate had nothing to do with distribution of urban and rural or provinces.We could not see significant relevance between the positive rate of measlesantibody and the weight of newborns. The negative rate of measles antibodywas14.75%in122child-bearing women and the positive rate of low antibodywas18.03%It showed that about33%women of child-bearing age maybeinfected.Conclusion：we should pay more attention to the infants(under1year) inmeasles controlling,So the measures to control infant measles are as following:firstly, to improve routine immunization coverage and quality,secondly, tointerrupt the wild measles virus circulation by increasing the immunizationcoverage among general population,and increase the immunization coverageamong the older children to prevent infants below8months old from beingexposed to measles infection,and lastly, to incorporate the measles vaccineimmunization to child-bearing aged women into measles control.