Relationship Between Serum CXCL5Levels And Insulin Resistance In Individuals With Obesity

Objective：To explore the relationship between serum CXCL5levels and insulinresistance in individuals with obesity or overweight and the association of serum CXCL5levels with anthropometric parameters, glucose-lipid metabolism parameters, in order toprovide some theoretical foundation for the occurrence of obesity and T2DM.Methods：106subjects with normal glucose regulation were divided into normalweight group (A,43cases)，overweight group(B,43cases) and obesity group (C,20,cases)according to BMI. Then we detected serum CXCL5levels and TNF-α of all subjectsby ELISA method. Fasting plasma glucose (FPG), insulin (FINS), glycosylatedhemoglobinA1c (HbA1c) and lipid profiles were measured as well. Insulin sensitivity wasassessed by HOMA-IR.Results：①Serum CXCL5levels in obesity group[(1204.63±272.75）pg/ml] and thatin overweight group[(1058.36±385.38）pg/ml] were significantly higher than those incontrol group [(874.06±394.51） pg/ml] according to ANOVA (P<0.01， P<0.05respectively); CXCL5levels in obesity group were significantly higher than those inoverweight group(P<0.05)②serum CXCL5levels in females[(1158.41±406.86)pg/ml]were higher than those in males[(910.72±343.41)pg/ml](p<0.05respectively)③SerumCXCL5levels were positively correlated with BMI, WC,WHR, TNF-α, TC and LDL-C(r=0.240,P=0.026; r=0.486,P=0.000; r=0.369,P=0.009; r=0.349,P=0.014;r=0.363,P=0.010;r=0.341,P=0.017, respectively), but not with HOMA-IR(P>0.05)④Stepwise regressionanalysis showed that WC（r=0.446, β=0.001）and LDL-C（r=0.276, β=0.031）were theindependent variables of CXCL5.Conclusion：①CXCL5might play a role in the path physiology of obesity and lipidmetabolism.②We didn’t find the correlation between CXCL5level and insulinresistance.③Sex hormone may affect serum CXCL5level.