Clinical Research On The Treatment Of Menopausal Syndromes Of Liver And Kidney Yin Deficiency With Modified Kidney-yin Reinforcing Pills

ObjectiveThe research mainly discusses the clinical curative effect of modified Kidney-yin Reinforcing Pills on various diseases around menopause due to liver and kidney yin deficiency. Clinically, syndromes around menopause are mainly due to liver and kidney yin deficiency. This research adopts Kidney-yin Reinforcing Pill for treatment. The control study takes acupoint injection of angelica injection in combination with Five Seeds Combo injection. Observe clinical curative effect of Kidney-yin Reinforcing Pills in the treatment of menopausal syndromes due to liver and kidney yin deficiency and make preliminary exploration of its mechanism.MethodsThe subjects are patients of menopausal syndromes due to liver and kidney yin deficiency. Classify the60qualified cases of patients randomly into the Treatment Group and Control Group.30cases are in the Treatment Group and take modified Kidney-yin Reinforcing pills orally.30cases are in the Control Group and take acupoint injection of angelica injection in combination with Five Seeds Combo injection. The Treatment Group:The prescription is modified Kidney-yin Reinforcing Pill. Ingredients (basic prescription):prepared rhizome of rehmannia24g, red osier12g, Chinese yam12g, radix bupleuri12g, medlar15g, dodder10g, deer-horn glue10g, tortoise plastron glue10g, radix achyranthis10g, cassia pulp10g, angelica10g, semen platycladi20g, fructus amomi6g. For insomnia, add Semen Ziziphi Spinosae30g; for palpitations and sweating, add calcined os draconis30g and oyster30g; for eyelid and lower limb swelling, add poria cocos10g and rhizome alismatis10g; for waist and knee pain, add eucommia ulmoides10g and radix achyranthis15g. Decoct in warm water and take1dose per day twice with half dose each time.10days make1treatment course. Use statistics to evaluate the curative effect. The Control Group:Conduct acupoint injection of angelica injection in combination with Five Seeds Combo injection.10days make1treatment course and observe for3consecutive courses.When the treatment finishes, observe the improvement of major symptoms before and after treatment of two groups. Evaluate with the score scale about syndrome. Calculate the total value before and after treatment and find the difference. Evaluate the safety from aspects of blood, urine and stool routines, cardiogram results, liver function and kidney function.After the clinical research, clinical material is timely summarized. Use computer for data management. Build a database with Epi Data3.01software. Use SPSS software for statistical analysis.Statistical methods:classification material is tested withx2inspection, ranked data samples are tested with Wilcoxon rank sum test (correction), and the self AP comparison is made with pairing t test or Wilcoxon pairing rank sum test. For statistics, use SPSS17.0software.ResultsThe study participants were60qualified subjects, with30cases in the Treatment Group and30in the Control Group. The total effective rate of the Treatment Group is superior to that of the control medicine.Two groups’total curative effect comparison shows significant difference, and the Treatment Group is superior to the Control Group.The Treatment Group:the full recovery rate is16.67%, the excellence rate is46.67%, the effective rate is30%, and the total effective rate is93.3%; The Control Group:the full recovery rate is13.33%, the excellence rate is36.67%, the effective rate is36.67%, and the total effective rate is86.67%. Two groups’comparison shows significant difference.Two groups’TCM syndrome curative effect comparison shows significant difference and the Treatment Group is superior to the Control Group.The Treatment Group:the clinical cure rate is20%, the excellence rate is43.33%, the effective rate is26.67%, and the total effective rate is90%; The Control Group:the clinical cure rate is16.67%, the excellence rate is43.33%, the effective rate is23.33%, and the total effective rate is83.3%. Two groups’comparison shows significant difference.Symptom score:After treatment, the Treatment Group’s and the Control Group’s respective symptom scores decreased (P<0.01). Two groups’ difference value comparison before and after treatment has significance (P <0.01), indicating that the Treatment Groups has better effect than the Control Group in improving symptoms.The main symptoms:Two groups are both effective for the treatment of major symptoms like flashing heat, insomnia, irritability and fatigue, etc. The Treatment Group has better curative effect and improvement than the Control Group (P<0.05).ConclusionUsing modified Kidney-yin Reinforcing Pills to treat menopausal syndromes of liver and kidney yin deficiency can significantly improve patients’main symptoms and clinical application safety.