Clinical Research By Applying The Method Of Jian Pi Huo Xue In Treating Spleen Deficiency And Blood Stasis Syndrome Of Chronic Atrophic Gastritis

Objective:To observe the clinical effect and safety by using the method of JianPiHuoXue prescription in treating Chronic Atrophic Gastritis with Spleen deficiency and Blood stasis Syndrome. And observe the long-term curative effect after following up for3months.Methods:This research was based on63cases of outpatients who were conformed to inclusion criteria. They were randomly divided into two groups. One group was the treatment group,32patients of which were treated by JianPiHuoXue prescription. The other group was the control group, with31patients being treated WeiFuChun. Both groups were treated for three months. Then we can observe the clinical effect when the course was finished. Long-term observation would be carry on after stop using treatment for three months.Result:1.The overall curative effect comparison of two groups after the treatment:In the test group,2cases recovered and14cases significantly improved,13cases improved,3ineffectual cases. The total effective rate of test group was90.63%. In the control group,2cases recovered and7cases significantly improved,12cases improved,10ineffectual cases. The total effective rate of control group was67.74%. There was statistically significant difference in the total effective rate between the treatment group and control guoup(P<0.05). The effective rate from the test group was clearly superior.Comparison within groups found:Excepting diarrhoea and astriction were of no avail(P>0.05), the two groups both had curative effect to the other syndromes(P<0.05). Comparison among groups found:The test group has symptomatic improvement in stomach bloated,stomach pain.stomach noisy and diet reduction. The comparison of two groups had statistical significance(P<0.05or P<0.01). The time of test group on alleviating stomach bloated and tired was shorter than the control group. Other syndromes had curative effect almost in the same time of the two groups.2.The two groups both reexamined the gastrofiberscope, and the comparison of curative effect of two groups of histopathology after the treatment found:The total efficiency of gastric atrophy,intestinal metaplasia of two groups was65.63%and68.75%respectively,while the control group was45.16%and48.39%respectively. The comparison of two groups had statistical significance(P<0.05).The improvement rate of inflammatory activity and H.pylori infection of test group was also better than the control group(P<0.05). But dysplasia and chronic inflammation curative effect between the two groups had no obvious statistical significance(P>0.05).3.After three months of untreatment,5cases recovered,16cases significantly improved,9cases improved and1ineffectual cases in the test group. The total effective rate of test group was96.88%. In the control group,1cases recovered,10cases significantly improved,10cases improved and10ineffectual cases. The total effective rate of control group was67.74%. There was statistically significant difference in the total effective rate between the treatment group and control guoup(P<0.01).The long-term clinical efficacy of the test group was better than the control group.4.In the observation, the two groups both didn’t find significant adverse reaction.Conclusion:JianPiHuoXue prescription has significant efficacy in treating Chronic Atrophic Gastritis with Spleen deficiency and Blood stasis Syndrome.The prescription can improve clinical symptoms and pathology, besides it also has good security.